Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

doi:10.1007/s10118-016-1787-3

Your Location：

Home >

Browse articles >

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

Papers | Updated：2022-02-21

- Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems
- Vol. 34, Issue 6, Pages: 679-687(2016)
- Affiliations：
  
  a.College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
  b.Department of Urology, West China Hospital, Huaxi Clinical College, Sichuan University, Chengdu 610065, China
  c.Research Institute for Strengthening Technology, Sichuan Institute of Building Research, Chengdu 610081, China
- Author bio：
  
  Jie-hua Li (李洁华), E-mail: jiehua_li@scu.edu.cn
  Hong Tan (̷谭鸿), E-mail: hongtan@scu.edu.cn
- Funds：
  
  This work was financially supported by the National Natural Science Foundation of China(Nos. 51173118, 51273124 and 51273126);the National Science Fund for Distinguished Young Scholars of China(No. 51425305);the Youth Science and Technology Innovation Team of Sichuan Province(No. 2015TD0001);and State Key Laboratory of Polymer Materials Engineering(No. sklpme2014-2-03)
- DOI：10.1007/s10118-016-1787-3
  CLC：
- Received：21 November 2015，
  
  Revised：2016-1-24，
  
  Accepted：02 February 2016，
  
  Published：2016-06
- Accepted：
Scan QR Code
Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 2016, 34(6): 679-687.
DOI：

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. 2016, 34(6): 679-687. DOI： 10.1007/s10118-016-1787-3.

摘要

Abstract

In this study

to improve hemocompatibility of biomedical materials

a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated

via

simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin

as determined by the toluidine blue method. Furthermore

the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption

platelet adhesion

activated partial thromboplastin time (APTT)

thrombin time (TT)

hemolysis

and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus

the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.

关键词

Keywords

references

M.D Lelah, , S.L. Cooper, . "Polyurethanes in medicine" . CRC Press, Boca Raton , 1986 . p.225 .

Ritter, H., "Desk reference of functional polymers, syntheses and applications", American Chemical Society, Washington, 1997, p.103

P. Qi, , Y. Yang, , F.M Maitz, , N. Huang, . . Chinese Sci. Bull. , 2013 . 58 ( 35 ): 4362 .

H. Zhang, , Y. She, , X Zheng, , H.Y. Chen, . . Chinese J. Polym. Sci. , 2014 . 32 ( 10 ): 1363 .

Q. Xing, , R.B. Li, , X.Q. Zhang, , L.Y Zhang, , D.J. Wang, . . Chinese J. Polym. Sci. , 2015 . 33 ( 9 ): 1294 .

K.N. Sask, , L.R. Berry, , A.K Chan, , J.L. Brash, . . Langmuir , 2011 . 28 ( 4 ): 2099 .

E.A. Aksoy, , V. Hasirci, , N. Hasirci, , A. Motta, , M Fedel, , C. Migliaresi, . . J. Bioact. Compat. Polym. , 2008 . 23 ( 6 ): 505 .

D.K. Han, , S.Y. Jeong, , K.D. Ahn, , Y.H Kim, , B.G., J. Biomater. Sci. Min, . . Polym. Ed. , 1993 . 4 ( 6 ): 579 .

M. Tan, , Y. Feng, , H. Wang, , L. Zhang, , M. Khan, , J. Guo, , Q Chen, , J. Liu, . . Macromol. Res. , 2013 . 21 ( 5 ): 541 .

J. Yuan, , Y.L. Yuan, , J. Shen, , S.C. Lin, , W Zhu, , J.L. Fang, . . Chinese J. Polym. Sci. , 2003 . 21 ( 4 ): 419 .

Hirsh, J., Raschke, R., Warkentin, T.E., Dalen, J.E., Deykin, D. and Poller, L., Chest J., 1995,108(4_Supplement): 258S

B. Mulloy, , J Hogwood, , E. Gray, . . Biologicals , 2010 . 38 ( 4 ): 459 .

Y.J. Kim, , I.K. Kang, , M.W Huh, , S.C. Yoon, . . Biomaterials , 2000 . 21 ( 2 ): 121 .

G. Bernacca, , M. Gulbransen, , R Wilkinson, , D. Wheatley, . . Biomaterials , 1998 . 19 ( 13 ): 1151 .

J.S. Bae, , E.J Seo, , I.K. Kang, . . Biomaterials , 1999 . 20 ( 6 ): 529 .

Y.K. Sung, , Y.J Kim, , S.W. Kim, . . Chinese J. Polym. Sci. , 1999 . 17 ( 2 ): 113 .

H.T. Moon, , Y.K. Lee, , J.K Han, , Y. Byun, . . Biomaterials , 2001 . 22 ( 3 ): 281 .

A.B. Schreiber, , J. Kenney, , W.J. Kowalski, , R. Friesel, , T Mehlman, , T. Maciag, . . Proc. Natl. Acad. Sci. , 1985 . 82 ( 18 ): 6138 .

W. Marconi, , A. Galloppa, , A Martinelli, , A.J. Mater. Piozzi, . . Sci. Mater. Med. , 1994 . 5 ( 11 ): 779 .

F. Tong, , X. Chen, , L. Chen, , P. Zhu, , J. Luan, , C. Mao, , J Bao, , J.J. Mater. Shen, . . Chem. B , 2013 . 1 ( 4 ): 447 .

N.J. Song, , X. Jiang, , J.H. Li, , J.S Li, , Q. Fu, . . Chinese J. Polym. Sci. , 2013 . 31 ( 10 ): 1451 .

X. Jiang, , F. Yu, , Z. Wang, , J. Li, , H. Tan, , M Ding, , Q., J. Biomater. Sci. Fu, . . Polym. Ed. , 2010 . 21 ( 12 ): 1637 .

X. Jiang, , J. Li, , M. Ding, , H. Tan, , Q. Ling, , Y Zhong, , Q. Fu, . . Eur. Polym. J. , 2007 . 43 ( 5 ): 1838 .

P. Smith, , A Mallia, , G. Hermanson, . . Anal. Biochem. , 1980 . 109 ( 2 ): 466 .

M. Ding, , J. Li, , X. Fu, , J. Zhou, , H. Tan, , Q Gu, , Q. Fu, . . Biomacromolecules , 2009 . 10 ( 10 ): 2857 .

H. Yang, , H. Xu, , G. Zhu, , C. Ouyang, , X Wang, , W. Xu, . . Proc. Inst. Mech. Eng. H , 2011 . 225 ( 4 ): 421 .

Shriver, Z., Capila, I., Venkataraman, G. and Sasisekharan, R., "Heparin-a century of progress", Springer, Berlin Heidelberg, 2012, p.159

H. Jiang, , X. Wang, , C. Li, , J. Li, , F. Xu, , C. Mao, , W Yang, , J. Shen, . . Langmuir , 2011 . 27 ( 18 ): 11575 .

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Multifunctional Polyurethane with High Strength, Toughness, and Self-healing Capacity via Tannic Acid-modified Cellulose Nanocrystals

Multifunctional Waterborne Polyurethane Nanocomposite Films with Remarkable Electromagnetic Interference Shielding, Electrothermal and Solarthermal Performances

Carbon Dots Intensified Mechanochemiluminescence from Waterborne Polyurethanes as Tunable Force Sensing Materials

pH-Responsive L-Cysteine-conjugated Polydopamine Nanocarriers for Controlled Release of Emamectin Benzoate against Pieris brassicae

2026-9 Contents

Related Author

Yong Wang

Jing-Hui Yang

Xiao-Dong Qi

De-Xiang Sun

Chao-Qun Wu

Dan-Min Wu

Zhong-Zhen Yu

Xin-Feng Zhou

Related Institution

Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Chemistry, Southwest Jiaotong University

Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology

State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology

Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Tianjin University

GDHPPC Lab, School of Chemistry, Sun Yat-sen University

⁰