Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

Meng-jiao Dong; Shun-li Liu; Lin-hua Tan; Lian Cen; Guo-dong Fu

doi:10.1007/s10118-016-1783-7

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Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

PAPERS | Updated：2021-05-12

- Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks
- Chinese Journal of Polymer Science Vol. 34, Issue 5, Pages: 637-648(2016)
- Affiliations：
  
  a.School of Chemistry and Chemical Engineering, Southeast University, Jiangning District, Nanjing 211189, China
  b.Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
  c.National Tissue Engineering Center of China, Shanghai 200241, China
- Author bio：
  
  Lian Cen (岑莲), E-mail: cenlian@hotmail.com
  Guo-dong Fu (付国东), E-mail: fu7352@seu.edu.cn
- Funds：
- DOI：10.1007/s10118-016-1783-7
  CLC：
- Received：23 November 2015，
  
  Revised：2016-1-12，
  
  Accepted：12 January 2016，
  
  Published：2016-05
- Accepted：
Scan QR Code
Meng-jiao Dong, Shun-li Liu, Lin-hua Tan, et al. Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks[J]. Chinese Journal of Polymer Science, 2016, 34(5): 637-648.
DOI：

Meng-jiao Dong, Shun-li Liu, Lin-hua Tan, et al. Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks[J]. Chinese Journal of Polymer Science, 2016, 34(5): 637-648. DOI： 10.1007/s10118-016-1783-7.

摘要

Abstract

The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized

via

the reaction of copper(I)-catalyzed 1

3-dipolar azide-alkyne cycloaddition (CuAAC) with poly(ethylene glycol)-dopamine (PEG-DA) (“Click Chemistry”) followed by complexation with Fe

ions to crosslink the polymeric network. The chemical composition and morphology of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR)

H-NMR and scanning electron microscopy (SEM). Swelling ratio

mechanical strength

conductivity

and degradation behaviors of the hydrogels were also studied. The effect of the polymer chain length on properties of hydrogels was explored. The compressive strength of hydrogels could reach as high as 13.1 MPa with a conductivity of 2.2×10

-5

S·cm

-1

. The hydrogels also exhibited excellent thermal stability even at a temperature of 300 ℃

whereas degradation of the hydrogel after 7 weeks was observed under a physiological condition. In addition

the hydrogel exhibited a good biocompatibility based on its

in vivo

performance through an

in vivo

subcutaneous implantation model. No inflammation and no obvious abnormality of the surrounding tissue were observed when the hydrogel was subcutaneously implanted for 2 weeks. This work is a step towards creating a new pathway to synthesize hydrogels of interpenetrating networks which could be of important applications in the future research.

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references

A.S. Hoffman . Adv. Drug Delivery Rev. , 2012 . 64 18 DOI: 10.1016/j.addr.2012.09.010 http://doi.org/10.1016/j.addr.2012.09.010 .

A.K. Zhang , J. Ling , Y.W. Sun , G.D. Fu . Chinese J. Polym. Sci. , 2015 . 33 ( 5 ): 721 DOI: 10.1007/s10118-015-1620-4 http://doi.org/10.1007/s10118-015-1620-4 .

M. Malkoch , R. Vestberg , N. Gupta , L. Mespouille , P. Dubois , A.F. Mason , J. L. Hedrick , Q. Liao , C.W. Frank , K. Kingsbury . Chem. Commun. , 2006 . 2774 .

W.J. Li , R. Tuli , C. Okafor , A. Derfoul , K.G. Danielson , D.J. Hall , R.S. Tuan . Biomaterials , 2005 . 26 599 DOI: 10.1016/j.biomaterials.2004.03.005 http://doi.org/10.1016/j.biomaterials.2004.03.005 .

G. Molinaro , J.C. Leroux , J. Damas , A. Adam . Biomaterials , 2002 . 23 2717 DOI: 10.1016/S0142-9612(02)00004-2 http://doi.org/10.1016/S0142-9612(02)00004-2 .

X.Z. Shu , Y. Liu , F.S. Palumbo , Y. Luo , G.D. Prestwich . Biomaterials , 2004 . 25 1339 DOI: 10.1016/j.biomaterials.2003.08.014 http://doi.org/10.1016/j.biomaterials.2003.08.014 .

A. Kikuchi , T. Okano . Adv. Drug Delivery Rev. , 2002 . 54 53 DOI: 10.1016/S0169-409X(01)00243-5 http://doi.org/10.1016/S0169-409X(01)00243-5 .

J.B. Leach , C.E. Schmidt . Biomaterials , 2005 . 26 125 .

G. Orlando , P. Baptista , M. Birchall , Coppi P. De , A. Farney , N.K. Guimaraes-Souza , E. Opara , J. Rogers , D. Seliktar , K. Shapira-Schweitzer . Transplant Int. , 2011 . 24 223 .

B.V. Slaughter , S.S. Khurshid , O.Z. Fisher , A. Khademhosseini , N.A. Peppas . Adv. Mater. , 2009 . 21 3307 DOI: 10.1002/adma.v21:32/33 http://doi.org/10.1002/adma.v21:32/33 .

O. Lieleg , K. Ribbeck . Trends Cell Biol. , 2011 . 21 543 DOI: 10.1016/j.tcb.2011.06.002 http://doi.org/10.1016/j.tcb.2011.06.002 .

K. Haraguchi , T. Takehisa . Adv. Mater. , 2002 . 14 1120 DOI: 10.1002/1521-4095(20020816)14:16<1120::AID-ADMA1120>3.0.CO;2-9 http://doi.org/10.1002/1521-4095(20020816)14:16<1120::AID-ADMA1120>3.0.CO;2-9 .

M.V. Risbud , R.R. Bhonde . Drug Deliv. , 2000 . 7 69 DOI: 10.1080/107175400266623 http://doi.org/10.1080/107175400266623 .

Z.B. Zhao , S.S. An , H.J. Xie , Y. Jiang . Chinese J. Polym. Sci. , 2015 . 33 ( 1 ): 173 DOI: 10.1007/s10118-015-1565-7 http://doi.org/10.1007/s10118-015-1565-7 .

H. Feil , Y. Bae , J. Feijen , S. Kim . Macromolecules , 1992 . 25 5528 DOI: 10.1021/ma00046a063 http://doi.org/10.1021/ma00046a063 .

L.F. Gudeman , N.A. Peppas . J. Appl. Polym. Sci. , 1995 . 55 919 DOI: 10.1002/app.1995.070550610 http://doi.org/10.1002/app.1995.070550610 .

C.L. Qin , W.M. Cai , J. Cai , D.Y. Tang , J.S. Zhang , M. Qin . Mater. Chem. Phys. , 2004 . 85 402 DOI: 10.1016/j.matchemphys.2004.01.019 http://doi.org/10.1016/j.matchemphys.2004.01.019 .

T. Jeevananda . Eur. Polym. J. , 2003 . 39 569 DOI: 10.1016/S0014-3057(02)00272-0 http://doi.org/10.1016/S0014-3057(02)00272-0 .

C.H. Chen , M.H. Chen . J. Appl. Polym. Sci. , 2006 . 100 323 DOI: 10.1002/(ISSN)1097-4628 http://doi.org/10.1002/(ISSN)1097-4628 .

S.J. Kim , S.J. Park , S.I. Kim . React. Funct. Polym. , 2003 . 55 53 DOI: 10.1016/S1381-5148(02)00214-6 http://doi.org/10.1016/S1381-5148(02)00214-6 .

D. Myung , W. Koh , J. Ko , Y. Hu , M. Carrasco , J. Noolandi , C.N. Ta , C.W. Frank . Polymer , 2007 . 48 5376 DOI: 10.1016/j.polymer.2007.06.070 http://doi.org/10.1016/j.polymer.2007.06.070 .

C. Zhou , S.S. Qian , X.J. Li , F. Yao , J.S. Forsythe , G.D. Fu . RSC Adv. , 2014 . 4 54631 DOI: 10.1039/C4RA09438G http://doi.org/10.1039/C4RA09438G .

M. Wang , Y. Fang , D. Hu . React. Funct. Polym. , 2001 . 48 ( 1 ): 215 .

X.Z. Zhang , D.Q. Wu , C.C. Chu . Biomaterials , 2004 . 25 ( 17 ): 3793 DOI: 10.1016/j.biomaterials.2003.10.065 http://doi.org/10.1016/j.biomaterials.2003.10.065 .

M. Suzuki , K. Hanabusa . Chem. Soc. Revi. , 2010 . 39 ( 2 ): 455 DOI: 10.1039/B910604A http://doi.org/10.1039/B910604A .

S. Yunoki , T. Suzuki , M. Takai . J. Biosci. Bioeng. , 2003 . 96 ( 6 ): 575 DOI: 10.1016/S1389-1723(04)70152-8 http://doi.org/10.1016/S1389-1723(04)70152-8 .

O. Bistri , K. Mazeau , R. Auzély-Velty , M. Sollogoub . Chem. Eur. J. , 2007 . 13 ( 31 ): 8847 DOI: 10.1002/(ISSN)1521-3765 http://doi.org/10.1002/(ISSN)1521-3765 .

S.H. Allan . Adv. Drug Delivery Rev. , 2012 . 64 18 DOI: 10.1016/j.addr.2012.09.010 http://doi.org/10.1016/j.addr.2012.09.010 .

C.A. DeForest , B.D. Polizzotti , K.S. Anseth . Nat. Mater. , 2009 . 8 659 DOI: 10.1038/nmat2473 http://doi.org/10.1038/nmat2473 .

H. Altin , I. Kosif , R. Sanyal . Macromolecules , 2010 . 43 3801 DOI: 10.1021/ma100292w http://doi.org/10.1021/ma100292w .

F.T. Zohora , A.Y.M.A. Azim . Eur. Sci. J. , 2014 . 10 ( 21 ): 186 .

Y. Xu , B. Zhang , S. Wu , Y. Xia . Anal. Chim. Acta , 2009 . 649 ( 1 ): 117 DOI: 10.1016/j.aca.2009.06.058 http://doi.org/10.1016/j.aca.2009.06.058 .

L. Xu , F. Yao , G. Fu , E. Kang . Biomacromolecules , 2010 . 11 1810 DOI: 10.1021/bm100268t http://doi.org/10.1021/bm100268t .

S. Qian , C. Zhou , L. Xu , F. Yao , L. Cen , G. Fu . RSC Adv. , 2014 . 4 25241 DOI: 10.1039/C4RA01870B http://doi.org/10.1039/C4RA01870B .

V.S. Wilms , H. Bauer , C. Tonhauser , A.M. Schilmann , M.C. Müller , W. Tremel , H. Frey . Biomacromolecules , 2012 . 14 193 .

D.D. Díaz , S. Punna , P. Holzer , A.K. McPherson , K. B. Sharpless , V.V. Fokin , M. Finn , Polym. Sci. J. . Part A: Polym. Chem. , 2004 . 42 4392 DOI: 10.1002/pola.20330 http://doi.org/10.1002/pola.20330 .

B. Fei , B. Qian , Z. Yang , R. Wang , W. Liu , C. Mak , J.H. Xin . Carbon , 2008 . 46 1795 DOI: 10.1016/j.carbon.2008.06.049 http://doi.org/10.1016/j.carbon.2008.06.049 .

D.L. Merlin , B. Sivasankar . Eur. Polym. J. , 2009 . 45 165 DOI: 10.1016/j.eurpolymj.2008.10.012 http://doi.org/10.1016/j.eurpolymj.2008.10.012 .

C.H. Chen , W.J. Chen , M.H. Chen , Y.M. Li . Polymer , 2000 . 41 7961 DOI: 10.1016/S0032-3861(00)00173-7 http://doi.org/10.1016/S0032-3861(00)00173-7 .

A. Mathew , S. Packirisamy , H. Radusch , S. Thomas . Eur. Polym. J. , 2001 . 37 1921 DOI: 10.1016/S0014-3057(01)00067-2 http://doi.org/10.1016/S0014-3057(01)00067-2 .

Y. Chen , L. Chen , H. Bai , L. Li . J. Mater. Chem. A , 2013 . 1 1992 DOI: 10.1039/C2TA00406B http://doi.org/10.1039/C2TA00406B .

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