Synthesis and Characterization of <italic style="font-style: italic">D</italic>-/<italic style="font-style: italic">L</italic>-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers

Li-qi Dong; Du-fen Hu; Xue-min Duan; Zhi-peng Wang; Kai-xin Zhang; Xiao-fei Zhu; Hui Sun; You-shan Zhang; Jing-kun Xu

doi:10.1007/s10118-016-1772-x

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Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers

PAPERS | Updated：2021-05-12

- Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers
- Chinese Journal of Polymer Science Vol. 34, Issue 5, Pages: 563-577(2016)
- Affiliations：
  
  School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China
- Author bio：
  
  Xue-min Duan (段学民), E-mail: duanxuemin@126.com
  Jing-kun Xu (徐景坤), E-mail: xujingkun@tsinghua.org.cn
- Funds：
- DOI：10.1007/s10118-016-1772-x
  CLC：
- Received：31 October 2015，
  
  Revised：2015-12-5，
  
  Accepted：05 December 2015，
  
  Published：2016-05
- Accepted：
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Li-qi Dong, Du-fen Hu, Xue-min Duan, et al. Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers[J]. Chinese Journal of Polymer Science, 2016, 34(5): 563-577. DOI: 10.1007/s10118-016-1772-x.
DOI：

Li-qi Dong, Du-fen Hu, Xue-min Duan, et al. Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers[J]. Chinese Journal of Polymer Science, 2016, 34(5): 563-577. DOI: 10.1007/s10118-016-1772-x. DOI：

摘要

Abstract

Two pairs of amino-acid functionalized poly(3

4-ethylenedioxythiophene) (PEDOT) derivatives

namely

poly(

tert

-butoxycarbonyl)-

-methionyl (3

4-ethylenedioxythiophene-2'-yl)methylamide) (

-PEDOT-Boc-Met) and poly(

tert

-butoxycarbonyl)-

-methionyl (3

4-ethylenedioxythiophene-2'-yl)methylamide) (

-PEDOT-Boc-Met); poly(

-methionyl (3

4-ethylenedioxythiophene-2'-yl)methylamide) (

-PEDOT-Met) and poly(

-methionyl (3

4-ethylenedioxythiophene-2'-yl)methylamide) (

-PEDOT-Met) were synthesized

via

chemical oxidative polymerization of corresponding monomers. The structural characterization

spectroscopic properties and thermal stability of these monomers and polymers were systematically explored by FTIR spectra

Raman spectra

XRD spectra

UV-Vis spectra and thermogravimetric analysis. As chiral electrode materials

these polymers were employed to successfully recognize 3

4-dihydroxyphenylalanine (DOPA) enantiomers by cyclic voltammetry (CV) in sulphuric acid solution. The measurement results reveal that the tendency was hetero-chiral interaction between

-PEDOT-Met/PVA/GCE and

-DOPA

-PEDOT-Met/PVA/GCE and

-DOPA

respectively. Also

the mechanism of chiral discrimination was discussed. All the results implied that the combination of electrochemical molecular recognition technology and chiral PEDOT materials can be a promising approach for chiral recognition and may open new opportunities for facile

biocompatible

sensitive and robust chiral assays in biochemical applications.

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references

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⁰

Synthesis and Characterization of D-/L-methionine Grafted PEDOTs for Selective Recognition of 3,4-Dihydroxyphenylalanine Enantiomers

DOI：10.1007/s10118-016-1772-x

摘要

Abstract

关键词

Keywords

references