Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

Ze-chuan Yang; Yan-chun Li; Fan Li; Qing-rong Huang; Guo Zhang; Tong-fei Shi

doi:10.1007/s10118-016-1757-9

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Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector

Updated：2021-06-21

- Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector
- Chinese Journal of Polymer Science Vol. 34, Issue 3, Pages: 280-287(2016)
- Affiliations：
  
  a.Institute of Materials Science and Engineering, Jilin University, Changchun 130012, China
  b.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Changchun 130021, China
  d.Food Science Department, Cook College Rutgers University, New Brunswick, NJ 08901-8520, United States
- Author bio：
  
  **Guo Zhang (张国), E-mail: guozhang@jlu.edu.cn
  Tong-fei Shi (石彤非), E-mail: tfshi@ciac.ac.cn
- Funds：
- DOI：10.1007/s10118-016-1757-9
  CLC：
- Received：13 August 2015，
  
  Revised：2015-10-14，
  
  Accepted：15 November 2015，
  
  Published：2016-03
- Accepted：
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Ze-chuan Yang, Yan-chun Li, Fan Li, et al. Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector[J]. Chinese Journal of Polymer Science, 2016, 34(3): 280-287.
DOI：

Ze-chuan Yang, Yan-chun Li, Fan Li, et al. Design and Preparation of pH-responsive Curdlan Hydrogels as a Novel Protein Delivery Vector[J]. Chinese Journal of Polymer Science, 2016, 34(3): 280-287. DOI： 10.1007/s10118-016-1757-9.

摘要

Abstract

New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives (curdlan-Bochistidine

CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L NaCl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin (BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover

the release profiles of BSA at different pH values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems.

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