Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Ming-zhi Wang; Tao Wang; Kang Yuan; Jianzhong Du

doi:10.1007/s10118-016-1725-4

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Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Updated：2021-06-21

- Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications
- Chinese Journal of Polymer Science Vol. 34, Issue 1, Pages: 44-51(2016)
- Affiliations：
  
  a.Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University, Shanghai 201804, China
  b.Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
- Author bio：
  
  † Both authors contributed equally to this work.
  **Jianzhong Du (杜建忠), E-mail: jzdu@tongji.edu.cn
- Funds：
- DOI：10.1007/s10118-016-1725-4
  CLC：
- Received：22 June 2015，
  
  Revised：2015-07-24，
  
  Accepted：24 July 2015，
  
  Published：2016-01
- Accepted：
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Ming-zhi Wang, Tao Wang, Kang Yuan, et al. Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications[J]. Chinese Journal of Polymer Science, 2016, 34(1): 44-51.
DOI：

Ming-zhi Wang, Tao Wang, Kang Yuan, et al. Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications[J]. Chinese Journal of Polymer Science, 2016, 34(1): 44-51. DOI： 10.1007/s10118-016-1725-4.

摘要

Abstract

We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer

poly(methyl methacrylate) (PMMA)

by copolymerizing methyl methacrylate (MMA) with 2-(

tert

-butylamino)ethyl methacrylate (TA) in one pot via atom transfer radical polymerization (ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-

tert

-butylamino)ethyl methacrylate] (PMMA

-PTA

) diblock copolymer affords well-defined water-dispersible vesicles

which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria.

H-NMR and gel permeation chromatography (GPC) studies confirmed the successful synthesis of welldefined copolymer. Transmission electron microscopy (TEM)

atomic force microscopy (AFM) and dynamic light scattering (DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover

this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.

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Special Topic: Chirality in Polymers

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