Biodegradable Microspheres with Poly(<italic style="font-style: italic">N</italic>-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

Yin Yuan; Pei-jian Sun; Xu-dong Shi; Zhi-hua Gan; Fo-song Wang

doi:10.1007/s10118-015-1702-3

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Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

PAPER | Updated：2021-06-21

- Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release
- Chinese Journal of Polymer Science Vol. 33, Issue 11, Pages: 1598-1605(2015)
- Affiliations：
  
  a.CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Sciences and Technology, Beijing 100029, China
- Author bio：
  
  **Pei-jian Sun (孙培健), E-mail: pjsun@iccas.ac.cn
  Fo-song Wang (王佛松), E-mail: wangfs@iccas.ac.cn
- Funds：
- DOI：10.1007/s10118-015-1702-3
  CLC：
- Received：23 April 2015，
  
  Accepted：28 April 2015，
  
  Published：2015-11
- Accepted：
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Yin Yuan, Pei-jian Sun, Xu-dong Shi, et al. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015, 33(11): 1598-1605. DOI: 10.1007/s10118-015-1702-3.
DOI：

Yin Yuan, Pei-jian Sun, Xu-dong Shi, et al. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, 2015, 33(11): 1598-1605. DOI: 10.1007/s10118-015-1702-3. DOI：

摘要

Abstract

Microspheres with thermo-responsible surface were fabricated by PCL-

-PEO-

-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-

-PEO-

-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (

e.g.

37 °C) were observed from porous surface structure to compact surface layer. Enzymatic degradation and

in vitro

drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-

-PEO copolymers

the drug release could be well regulated by changing temperatures and microspheres composition

which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release.

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Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

DOI：10.1007/s10118-015-1702-3

摘要

Abstract

关键词

Keywords

references