Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent

Hui-juan Du; Yan-chun Shen; Yu-ping Liu; Lin Han; Yao Zheng; Guo-ping Yan; Yuan-yuan Tu; Jiang-yu Wu; Qing-zhong Guo; Yun-fei Zhang; Xiao-tian Xia; Xiao-li Lan; Yong-xue Zhang

doi:10.1007/s10118-015-1681-4

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Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent

PAPER | Updated：2021-06-21

- Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent
- Chinese Journal of Polymer Science Vol. 33, Issue 9, Pages: 1325-1333(2015)
- Affiliations：
  
  a.School of Material Science and Engineering, Wuhan Institute of Technology, Wuhan 430074, China
  b.Center for PET of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Author bio：
  
  **Guo-ping Yan (鄢国平), E-mail: guopyan2006@163.com
- Funds：
- DOI：10.1007/s10118-015-1681-4
  CLC：
- Received：11 February 2015，
  
  Revised：2015-03-24，
  
  Accepted：30 March 2015，
  
  Published：2015-09
- Accepted：
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Hui-juan Du, Yan-chun Shen, Yu-ping Liu, et al. Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent[J]. Chinese Journal of Polymer Science, 2015, 33(9): 1325-1333.
DOI：

Hui-juan Du, Yan-chun Shen, Yu-ping Liu, et al. Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent[J]. Chinese Journal of Polymer Science, 2015, 33(9): 1325-1333. DOI： 10.1007/s10118-015-1681-4.

摘要

Abstract

Folate-containing dextran ligand (FA-Dextran-DTPA) was synthesized by the incorporation of diethylenetriaminepentaacetic acid (DTPA) and folate (FA) as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by

H-NMR

FTIR

UV-Vis

average particle sizes and zeta potential

as well.

In vitro

properties including relaxivity

cytotoxicity assay

cellular uptake assay

and magnetic resonance imaging (MRI) were also evaluated. Compared with Gd-DTPA

FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover

FA-Dextran-DTPA-Gd showed enhanced signal intensities (SI) of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.

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