Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment

Jie Chen; Zi-xue Jiao; Lin Lin; Zhao-pei Guo; Cai-na Xu; Yan-hui Li; Hua-yu Tian; Xue-si Chen

doi:10.1007/s10118-015-1632-0

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Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment

PAPER | Updated：2021-06-21

- Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment
- Chinese Journal of Polymer Science Vol. 33, Issue 6, Pages: 830-837(2015)
- Affiliations：
  
  a.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, China
  b.School of Materials Science and Technology, Changchun University of Science and Technology, Changchun 130022, China
- Author bio：
  
  **Hua-yu Tian (田华雨), E-mail: thy@ciac.ac.cn
- Funds：
- DOI：10.1007/s10118-015-1632-0
  CLC：
- Received：26 September 2014，
  
  Revised：2014-10-17，
  
  Accepted：28 October 2014，
  
  Published：2015-06
- Accepted：
Scan QR Code
Jie Chen, Zi-xue Jiao, Lin Lin, et al. Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment[J]. Chinese Journal of Polymer Science, 2015, 33(6): 830-837.
DOI：

Jie Chen, Zi-xue Jiao, Lin Lin, et al. Polylysine-modified Polyethylenimines as siRNA Carriers for Effective Tumor Treatment[J]. Chinese Journal of Polymer Science, 2015, 33(6): 830-837. DOI： 10.1007/s10118-015-1632-0.

摘要

Abstract

Polyethylenimine-poly(L-lysine) (PEI-PLL) copolymer was synthesized

via

ring-opening polymerization of L-lysine

-carboxyanhydride (Lys(Z)-NCA) initiated by PEI. The complexation of PEI-PLL with siRNA was studied by particle size and zeta potential measurements. The flow cytometric analysis and confocal imaging showed its excellent intracellular trafficking ability. PEI-PLL displayed higher gene silencing efficiency and lower cytotoxicity than commercial PEI-25k

in vitro

. In the antitumor study

PEI-PLL was further combined with siVEGF and showed obviously tumor inhibition effect for the treatment of CT26 tumor model. Therefore

PEI-PLL is a promising siRNA carrier candidate for further antitumor treatment

in vivo

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