Cisplatin-loaded Poly(L-glutamic acid)-<italic style="font-style: italic">g</italic>-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

Yi-fei Li; Hai-yang Yu; Hai Sun; Jian-guo Liu; Zhao-hui Tang; Dan Wang; Lian-you Yu; Xue-si Chen

doi:10.1007/s10118-015-1624-0

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Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

PAPER | Updated：2021-06-21

- Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma
- Chinese Journal of Polymer Science Vol. 33, Issue 5, Pages: 763-771(2015)
- Affiliations：
  
  a.Departemnt of Orthopaedics, the Norman Bethune First Hospital of Jilin University, Changchun 130021, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Jilin Central Hospital, Jilin 132011, China
  d.Basic Medical College, Beihua University, Jilin 132013, China
  e.The Hospital of Jilin Chemical Industry Company, Jilin 132021, China
- Author bio：
  
  **Jian-guo Liu (刘建国), E-mail: jgliu.2005@aliyun.com
  Zhao-hui Tang (汤朝晖), E-mail: ztang@ciac.ac.cn
- Funds：
- DOI：10.1007/s10118-015-1624-0
  CLC：
- Received：17 September 2014，
  
  Revised：2014-10-21，
  
  Accepted：28 October 2014，
  
  Published：2015-05
- Accepted：
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Yi-fei Li, Hai-yang Yu, Hai Sun, et al. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015, 33(5): 763-771. DOI: 10.1007/s10118-015-1624-0.
DOI：

Yi-fei Li, Hai-yang Yu, Hai Sun, et al. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, 2015, 33(5): 763-771. DOI: 10.1007/s10118-015-1624-0. DOI：

摘要

Abstract

Herein

cisplatin-loaded poly(L-glutamic acid)-

-methoxy poly(ethylene glycol) nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an iRGD (internalizing RGD

CRGDKDPDC). The release rate of platinum from the cisplatin-loaded nanoparticles CDDP/PLG160-

-mPEG2K (CDDP-NPs) accelerated with the increase of the acidity of the environment.

In vitro

test demonstrated that CDDP-NPs could inhibit the proliferation of MNNG/Hos osteosarcoma cells with IC

(72 h) of 12.2 μg×mL

-1

In vivo

test for MNNG/Hos osteosarcoma tumor bearing mice exhibited that CDDP-NPs had comparable or slightly higher efficacy but significantly lower side effects in comparison with free CDDP. The coadministration of iRGD could further enhance the anticancer efficacy of CDDP-NPs against MNNG/Hos osteosarcoma without bringing obvious side effects. Therefore

CDDP-NPs using alone or with iRGD have great potential for the treatment of osteosarcoma.

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Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

DOI：10.1007/s10118-015-1624-0

摘要

Abstract

关键词

Keywords

references