A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing

Xiao-fei Huang; Jing-wei Jia; Zheng-ke Wang; Qiao-ling Hu

doi:10.1007/s10118-015-1580-8

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A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing

PAPER | Updated：2022-01-17

- A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing
- Chinese Journal of Polymer Science Vol. 33, Issue 2, Pages: 284-290(2015)
- Affiliations：
  
  MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  **Zheng-ke Wang (王征科), E-mail: wangzk@zju.edu.cn
  Qiao-ling Hu (胡巧玲), E-mail: huql@zju.edu.cn
- Funds：
- DOI：10.1007/s10118-015-1580-8
  CLC：
- Received：18 April 2014，
  
  Revised：2014-07-07，
  
  Accepted：15 July 2014，
  
  Published：2015-02
- Accepted：
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Xiao-fei Huang, Jing-wei Jia, Zheng-ke Wang, et al. A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing[J]. Chinese Journal of Polymer Science, 2015, 33(2): 284-290.
DOI：

Xiao-fei Huang, Jing-wei Jia, Zheng-ke Wang, et al. A Novel Chitosan-based Sponge Coated with Self-assembled Thrombin/Tannic Acid Multilayer Films as a Hemostatic Dressing[J]. Chinese Journal of Polymer Science, 2015, 33(2): 284-290. DOI： 10.1007/s10118-015-1580-8.

摘要

Abstract

In order to prepare a novel hemostatic dressing for uncontrolled hemorrhage

a porous chitosan sponge was coated with self-assembled (thrombin/tannic acid)

films

which were based on hydrogen bonding interactions between thrombin and tannic acid at physiologic pH. According to the whole blood clotting test

the coated chitosan sponges showed a significantly high rate of blood clotting due to the addition of thrombin. On the other hand

the storable half-life of immobilized thrombin is extended to 66.9 days at room temperature

which is 8.5 times longer than unfixed thrombin. It is because of the immobilization effect of

not only the porous structure of chitosan sponge but also the interactions between thrombin and tannic acid. In addition

the tannic acid has similar antibacterial effect to chitosan. Therefore

it is an excellent combination of chitosan

thrombin and tannic acid. Besides

all of materials in this research have been approved by the United States Food and Drug Administration (FDA). So the chitosan-based sponge is a promising candidate dressing for uncontrolled hemorrhage due to its storable

bio-safe and highly effective hemostatic properties.

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