Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Yan-bo Zhang; Jian-xun Ding; Wei-guo Xu; Jie Wu; Fei Chang; Xiu-li Zhuang; Xue-si Chen; Jin-cheng Wang

doi:10.1007/s10118-014-1551-5

Your Location：

Home >

Browse articles >

Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Updated：2021-06-21

- Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering
- Chinese Journal of Polymer Science Vol. 32, Issue 12, Pages: 1590-1601(2014)
- Affiliations：
  
  a.Department of Orthopedics, the Second Hospital of Jilin University, Changchun 130041, China
  b.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
- Author bio：
  
  **Jian-xun Ding (丁建勋), E-mail: jxding@ciac.ac.cn
  Fei Chang (常非), E-mail: ccfei_cn@hotmail.com
  Jin-cheng Wang (王金成), E-mail: jinchengwang@hotmail.com
- Funds：
- DOI：10.1007/s10118-014-1551-5
  CLC：
- Received：05 March 2014，
  
  Revised：2014-04-09，
  
  Accepted：16 April 2014，
  
  Published：2014-12
- Accepted：
Scan QR Code
Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, et al. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014, 32(12): 1590-1601.
DOI：

Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, et al. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, 2014, 32(12): 1590-1601. DOI： 10.1007/s10118-014-1551-5.

摘要

Abstract

Poly(lactide-

-glycolide)-poly(ethylene glycol)-poly(lactide-

-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions

and formed hydrogels as the increase of temperature at relatively high concentrations (

15 wt%). The favorable degradability of the hydrogel was confirmed by

in vitro

and

in vivo

degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

FERROFERRIC OXIDE/CHITOSAN SCAFFOLDS WITH THREE-DIMENSIONAL ORIENTED STRUCTURE

PREPARATION OF POROUS NANOCOMPOSITE SCAFFOLDS WITH HONEYCOMB MONOLITH STRUCTURE BY ONE PHASE SOLUTION FREEZE-DRYING METHOD

SYNTHETIC HYDROGELS AS SCAFFOLDS FOR MANIPULATING ENDOTHELIUM CELL BEHAVIORS

Multiple-Responsive Chiral Hydrogels from Helical Dendronized Poly(phenylacetylene)s

Advances in Polymer-based Circularly Polarized Luminescent Materials

Related Author

Jia-han Ke

Zheng-ke Wang

Yin-zhe Li

Qiao-ling Hu

Jie Feng

Yang Xu

Duo Zhang

Zong-liang Wang

Related Institution

Department of Chemical Engineering and Materials, Zhejiang University of Technology

Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Zhejiang University

Key Laboratory of Polymer Ecobiomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Department of Plastic and Cosmetic Surgery, First Hospital of Jilin University

MOE Key Laboratory for Non-equilibrium Condensed Matter and Quantum Engineering, Biomedical Engineering and Biomechanics Center, Department of Chemistry, School of Science, Xi'an Jiaotong University

⁰