How Does a Polymer Brush Repel Proteins?

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How Does a Polymer Brush Repel Proteins?

Note | Updated：2021-06-21

- How Does a Polymer Brush Repel Proteins?
- Chinese Journal of Polymer Science Vol. 32, Issue 11, Pages: 1575-1580(2014)
- Affiliations：
  
  Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China; and The Open Laboratory of Bond Selective Chemistry, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China
- Author bio：
  
  **Chi Wu (吴奇), E-mail: chiwu@cuhk.edu.hk
- Funds：
- DOI：10.1007/s10118-014-1539-1
  CLC：
- Received：01 August 2014，
  
  Revised：2014-08-16，
  
  Accepted：17 August 2014，
  
  Published：2014-11
- Accepted：
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Chi Wu. How Does a Polymer Brush Repel Proteins?[J]. Chinese Journal of Polymer Science, 2014, 32(11): 1575-1580.
DOI：

Chi Wu. How Does a Polymer Brush Repel Proteins?[J]. Chinese Journal of Polymer Science, 2014, 32(11): 1575-1580. DOI： 10.1007/s10118-014-1539-1.

摘要

Abstract

The captioned question has been addressed by the steric effect; namely

the adsorption of proteins on a surface grafted with linear polymer chains decreases monotonically as the grafting density increases. However

there is no quantitative and satisfactory explanation why the adsorption starts to increase when the grafting density is sufficiently high and why polyethylene glycol (PEG) still remains as one of the best polymers to repel proteins. After considering each grafted chain as a molecular spring confined inside a "tube" made of its surrounding grafted chains

we estimated how its free energy depends on the grafting density and chain length

and calculated its thermal energy-agitated chain conformation fluctuation

enabling us to predict an adsorption minimum at a proper grafting density

which agrees well with previous experimental results. We propose that it is such a chain fluctuation that slows down the adsorption kinetically.

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