Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles

Hua-jie Li; Zhong Yu; Shuang-ping Wang; Li-ming Zhang; Li-qun Yang

doi:10.1007/s10118-014-1517-7

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Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles

PAPER | Updated：2021-06-21

- Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles
- Chinese Journal of Polymer Science Vol. 32, Issue 10, Pages: 1413-1418(2014)
- Affiliations：
  
  a.Institute of Polymer Science, School of Chemistry and Chemical Engineering, Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composites and Functional Materials of Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China
  b.Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China
- Author bio：
  
  **Li-qun Yang (杨立群), E-mail: yanglq@mail.sysu.edu.cn
- Funds：
- DOI：10.1007/s10118-014-1517-7
  CLC：
- Received：14 March 2014，
  
  Revised：2014-05-23，
  
  Accepted：02 July 2014，
  
  Published：2014-10
- Accepted：
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Hua-jie Li, Zhong Yu, Shuang-ping Wang, et al. Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles[J]. Chinese Journal of Polymer Science, 2014, 32(10): 1413-1418.
DOI：

Hua-jie Li, Zhong Yu, Shuang-ping Wang, et al. Protection of Photoactivity of Photosensitizers by Amphiphilic Polysaccharide Micelles[J]. Chinese Journal of Polymer Science, 2014, 32(10): 1413-1418. DOI： 10.1007/s10118-014-1517-7.

摘要

Abstract

Photosensitizer (photosan)-encapsulated micelles were prepared by self-assembly of Photosan with two amphiphilic polysaccharide derivatives

including the cholesteryl conjugated sodium alginate derivative (CSAD) and the deoxycholic acid group conjugated chitosan derivative (DA-Chit). The results of UV-Vis and fluorescence spectroscopy indicated that the hydrogen bonding strength dominated the micelle formation. Methyl viologen was used as a model quencher of photosan. Using the steady-state fluorescence technology

the quenching constants were determined to be 2.05

1.88 and 0.30 L/mmol for the free photosan

the photosan-CSAD micelle and the photosan-DA-Chit micelle

respectively. This suggested that photosan was protected from quenching of methyl viologen by the polysaccharide micelles. In addition

the protection effect of the photosan-DA-Chit micelle was significantly stronger than that of the photosan-CSAD micelle. The photosan-DA-Chit micelle is thus anticipated for protection of photoactivity of photosan during the blood circulation process

in vivo

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