A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

Fa-ming Gong; Zuo-quan Zhang; Xiao-dong Chen; Lu Zhang; Xing-su Yu; Qi-hua Yang; Xin-tao Shuai; Bi-ling Liang; Du Cheng

doi:10.1007/s10118-014-1399-8

Your Location：

Home >

Browse articles >

A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

Updated：2021-06-21

- A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer
- Chinese Journal of Polymer Science Vol. 32, Issue 3, Pages: 321-332(2014)
- Affiliations：
  
  a.PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
  b.Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510630, China
  c.Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China
  d.Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
- Author bio：
  
  † These authors contributed equally to this work.
  Bi-ling Liang (梁碧玲), E-mail: liangbl@vip.tom.com
  **Du Cheng (程度), E-mail: chengdu@mail.sysu.edu.cn
- Funds：
- DOI：10.1007/s10118-014-1399-8
  CLC：
- Received：13 May 2013，
  
  Revised：2013-07-26，
  
  Accepted：07 August 2013，
  
  Published：2014-03
- Accepted：
Scan QR Code
Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, et al. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014, 32(3): 321-332.
DOI：

Fa-ming Gong, Zuo-quan Zhang, Xiao-dong Chen, et al. A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer[J]. Chinese Journal of Polymer Science, 2014, 32(3): 321-332. DOI： 10.1007/s10118-014-1399-8.

摘要

Abstract

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly(ethylene glycol)-poly(ε-caprolactone) (PEG-

-PCL) with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MRI scanner. The

signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles

via

tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles

cRGD/scFv-ErbB-PEG-PCL-SPION

have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Facile and One-step Direct Synthesis of Poly(valine) as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent

On-demand Peelable UV-curable Adhesives with Superior Bonding Strength: Rational Molecular Engineering of Cohesion-adhesion Synergy

Epoxy-functionalized Cyclohexane-based Ricinoleate Plasticizer: Synthesis, Performance Evaluation, and Plasticizing Mechanism

Enhanced Segment Mobility Promotes Stereocomplex Crystallization in Polymer Blends via Elevated Segmental Miscibility

Related Author

Jun Wu

Ya-Bin Meng

Qing-zhong Guo

Yong-xue Zhang

Xiao-li Lan

Xiao-tian Xia

Yun-fei Zhang

Hui-juan Du

Related Institution

School of Biomedical Engineering, Sun Yat-sen University

School of Material Science and Engineering, Wuhan Institute of Technology

Center for PET of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

⁰