EFFECT OF SURFACE CHARGE OF POLYMERIC MICELLES ON IN VITRO CELLULAR UPTAKE

Dan-hua Zhou; Jie Zhang; Guan Zhang; Zhi-hua Gan

doi:10.1007/s10118-013-1332-6

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EFFECT OF SURFACE CHARGE OF POLYMERIC MICELLES ON IN VITRO CELLULAR UPTAKE

Special Issue: In Memory of Prof. Bingzheng Jiang | Updated：2023-01-03

- EFFECT OF SURFACE CHARGE OF POLYMERIC MICELLES ON IN VITRO CELLULAR UPTAKE
- Chinese Journal of Polymer Science Vol. 31, Issue 9, Pages: 1299-1309(2013)
- Affiliations：
  
  a.CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
  b.State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  c.Novelty Research Station for SCI-TECH, Beijing University of Chemical Technology, Beijing 100029, China
  d.Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China
- Author bio：
  
  Jie Zhang (张杰), E-mail: zjie@mail.buct.edu.cn
  **Zhi-hua Gan (甘志华), E-mail: zhgan@iccas.ac.cn
- Funds：
- DOI：10.1007/s10118-013-1332-6
  CLC：
- Received：07 May 2013，
  
  Revised：2013-07-02，
  
  Accepted：04 July 2013，
  
  Published：2013-09
- Accepted：
Scan QR Code
Dan-hua Zhou, Jie Zhang, Guan Zhang, et al. EFFECT OF SURFACE CHARGE OF POLYMERIC MICELLES ON IN VITRO CELLULAR UPTAKE[J]. Chinese Journal of Polymer Science, 2013, 31(9): 1299-1309.
DOI：

Dan-hua Zhou, Jie Zhang, Guan Zhang, et al. EFFECT OF SURFACE CHARGE OF POLYMERIC MICELLES ON IN VITRO CELLULAR UPTAKE[J]. Chinese Journal of Polymer Science, 2013, 31(9): 1299-1309. DOI： 10.1007/s10118-013-1332-6.

摘要

Abstract

This work focuses on the interaction between polymeric micelles with different charged surfaces and cancer cells in order to study the influence of surface charge on the

in vitro

cellular uptake efficiency. The amphiphilic diblock copolymers poly(

-caprolactone)-

-poly(ethylene oxide) (PCL-

-PEO) with different functional groups at the end of hydrophilic block were synthesized. The functional groups endue the micelles with different charges on the surfaces. The cellular uptake of micelles to T-24 cells (human bladder tumor cells)

HepG2 cells (human liver hepatocellular carcinoma cell line) and Hela cells (human epithelial cervical cancer cells) was studied by means of flow cytometer and confocal laser scanning microscopy. The results indicate that the surface charges showed great influence on zeta potential of micelles at different pH values. The

in vitro

cellular uptake efficiency of micelles with different charged surfaces demonstrated different cellular uptake patterns to three kinds of cancer cells.

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