MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES

Guo-qiang Chen; Yang Wang

doi:10.1007/s10118-013-1280-1

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MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES

Special Issue: In Honor of the 80th Birthday of Professor Fosong Wang (Part I) | Updated：2023-01-03

- MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES
- Chinese Journal of Polymer Science Vol. 31, Issue 5, Pages: 719-736(2013)
- Affiliations：
  
  a.MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China
  b.Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China
  c.State Key Laboratory of Plant Physiology and Biochemistry, National Plant Gene Research Centre, College of Biological Sciences, China Agricultural University, Beijing 100193, China
- Author bio：
  
  **Guo-qiang Chen (陈国强), E-mail: chengq@mail.tsinghua.edu.cn
  Yang Wang (汪洋), E-mail: wangy@cau.edu.cn
- Funds：
- DOI：10.1007/s10118-013-1280-1
  CLC：
- Received：31 December 2012，
  
  Revised：2013-01-25，
  
  Accepted：15 February 2013，
  
  Published：2013-05
- Accepted：
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Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 719-736.
DOI：

Guo-qiang Chen, Yang Wang. MEDICAL APPLICATIONS OF BIOPOLYESTERS POLYHYDROXYALKANOATES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 719-736. DOI： 10.1007/s10118-013-1280-1.

摘要

Abstract

Microbial polyhydroxyalkanoates (PHAs) are a family of biopolyesters produced by many wild type and engineered bacteria. PHAs have diverse structures accompanied by flexible thermal and mechanical properties. Combined with their

in vitro

biodegradation

cell and tissue compatibility

PHAs have been studied for medical applications

especially medical implants applications

including heart valve tissue engineering

vascular tissue engineering

bone tissue engineering

cartilage tissue engineering

nerve conduit tissue engineering as well as esophagus tissue engineering. Most studies have been conducted in the authors’ lab in the past 20+ years. Recently

mechanism on PHA promoted tissue regeneration was revealed to relate to cell responses to PHA biodegradation products and cell-material interactions mediated by microRNA. Very importantly

PHA implants were found not to cause carcinogenesis during long-term implantation. Thus

PHAs should have a bright future in biomedical areas.

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