DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT

Lu-zhong Zhang; Ya-jun Zhang; Wei Wu; Xi-qun Jiang

doi:10.1007/s10118-013-1267-y

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DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT

Special Issue: In Honor of the 80th Birthday of Professor Fosong Wang (Part I) | Updated：2023-01-03

- DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT
- Chinese Journal of Polymer Science Vol. 31, Issue 5, Pages: 778-786(2013)
- Affiliations：
  
  a.Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering; Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, China
  b.Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China
- Author bio：
  
  **Wei Wu (武伟), E-mail: wuwei@nju.edu.cn
  Xi-qun Jiang (蒋锡群), E-mail: jiangx@nju.edu.cn
- Funds：
- DOI：10.1007/s10118-013-1267-y
  CLC：
- Received：19 December 2012，
  
  Revised：2013-01-10，
  
  Accepted：21 January 2013，
  
  Published：2013-05
- Accepted：
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Lu-zhong Zhang, Ya-jun Zhang, Wei Wu, et al. DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT[J]. Chinese Journal of Polymer Science, 2013, 31(5): 778-786.
DOI：

Lu-zhong Zhang, Ya-jun Zhang, Wei Wu, et al. DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT[J]. Chinese Journal of Polymer Science, 2013, 31(5): 778-786. DOI： 10.1007/s10118-013-1267-y.

摘要

Abstract

The

in vivo

behaviors of doxorubicin (DOX)-loaded dextran-poly(3-acrylamidophenylboronic acid) (Dextran- PAPBA) nanoparticles (NPs) were studied. The DOX-loaded NPs had a narrowly distributed diameter of

. 74 nm and mainly accumulated in liver of tumor-bearing mice after intravenous injection as demonstrated by

in vivo

real-time near infrared fluorescent imaging. The DOX contents in various tissues were quantified and consisted well with the results of fluorescent imaging. The biodistribution pattern of DOX-loaded NPs encourages us to investigate their liver tumor treatment by using an orthotopically implanted liver tumor model

revealing that the DOX-loaded NPs formulation had better antitumor effect than free DOX.

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