PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES

Zhen Pan; Ze-hua Qu; Zheng Zhang; Rong Peng; Ce Yan; Jian-dong Ding

doi:10.1007/s10118-013-1264-1

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PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES

Special Issue: In Honor of the 80th Birthday of Professor Fosong Wang (Part I) | Updated：2023-01-03

- PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES
- Chinese Journal of Polymer Science Vol. 31, Issue 5, Pages: 737-747(2013)
- Affiliations：
  
  State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China
- Author bio：
  
  **Jian-dong Ding (丁建东), Email: jdding1@fudan.edu.cn
- Funds：
- DOI：10.1007/s10118-013-1264-1
  CLC：
- Received：26 November 2012，
  
  Revised：2012-12-20，
  
  Accepted：24 December 2012，
  
  Published：2013-05
- Accepted：
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Zhen Pan, Ze-hua Qu, Zheng Zhang, et al. PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 737-747.
DOI：

Zhen Pan, Ze-hua Qu, Zheng Zhang, et al. PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES[J]. Chinese Journal of Polymer Science, 2013, 31(5): 737-747. DOI： 10.1007/s10118-013-1264-1.

摘要

Abstract

A facile technique is herein reported to fabricate three-dimensional (3D) polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration

a well-known biodegradable polymer poly(lactide-

-glycolide) (PLGA) was employed as matrix. Under the porogen-leaching strategy

the large and soft porogens of paraffin were modified by colliding with small and hard salt particles

which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells (BMSCs) of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.

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