ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL

Ping Ren; Yi-bo Wu; Wen-li Guo; Shu-xin Li; Ying Chen

doi:10.1007/s10118-013-1216-9

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ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL

PAPER | Updated：2023-01-03

- ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL
- Chinese Journal of Polymer Science Vol. 31, Issue 2, Pages: 285-293(2013)
- Affiliations：
  
  College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  Department of Material Science and Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China
- Author bio：
  
  **Wen-li Guo (郭文莉), E-mail: gwenli@bipt.edu.cn
- Funds：
- DOI：10.1007/s10118-013-1216-9
  CLC：
- Received：20 March 2012，
  
  Revised：2012-07-02，
  
  Accepted：04 July 2012，
  
  Published：2013-02
- Accepted：
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Ping Ren, Yi-bo Wu, Wen-li Guo, et al. ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL[J]. Chinese Journal of Polymer Science, 2013, 31(2): 285-293.
DOI：

Ping Ren, Yi-bo Wu, Wen-li Guo, et al. ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL[J]. Chinese Journal of Polymer Science, 2013, 31(2): 285-293. DOI： 10.1007/s10118-013-1216-9.

摘要

Abstract

To improve the hydrophilicity of poly(styrene-

-isobutylene-

-styrene) (SIBS)

this study focuses on the synthesis of novel functional ABA triblock copolymer thermoplastic elastomers (TPEs) with polyisobutylene (PIB) as rubbery segments. The precursor poly{(styrene-

-4-[2-(

tert

-butyldimethylsiloxy) ethyl]styrene)-

-isobutylene-

-(styrene-

-4-[2-(

tert

-butyldimethylsiloxy)ethyl]styrene)}(P(St-

-TBDMES)-PIB-P(St-

-TBDMES)) triblock copolymer was first synthesized by living sequential cationic copolymerization of isobutylene (IB) with styrene (St) and 4-[2-(

tert

-butyldimethylsiloxy) ethyl]styrene (TBDMES) using 1

4-di(2-chloro-2-propyl)benzene (DiCumCl)/titanium tetrachloride (TiCl

)/2

6-di-

tert

-butylpyridine (D

BP) as the initiating system. Then

P(St-

-TBDMES)-PIB-P(St-

-TBDMES) was hydrolyzed in the presence of tetra-butylammonium fluoride to yield poly{[styrene-

-4-(2-hydroxyethyl)styrene]-bisobutylene-

-[styrene-

-4-(2-hydroxyethyl)styrene]} (P(St-

-HOES)-PIB-P(St-

-HOES)) with pendant hydroxyl groups. P(St-

-HOES)-PIB-P(St-

-HOES) used as the paclitaxel carrier was also investigated in this study. Comparing with SIBS

P(St-

-HOES)-PIB-P(St-

-HOES) has exhibited better compatibility with paclitaxel and higher release rate.

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