PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES

Wei-fang Tong; Xiao-li Liu; Fei Pan; Zhao-qiang Wu; Wen-wen Jiang

doi:10.1007/s10118-013-1210-2

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PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES

PAPER | Updated：2023-01-03

- PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES
- Chinese Journal of Polymer Science Vol. 31, Issue 3, Pages: 495-502(2013)
- Affiliations：
  
  a.Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
  b.College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China
- Author bio：
  
  **Zhao-qiang Wu (武照强), E-mail: wzqwhu@suda.edu.cn
- Funds：
- DOI：10.1007/s10118-013-1210-2
  CLC：
- Received：06 June 2012，
  
  Revised：2012-07-01，
  
  Accepted：03 July 2012，
  
  Published：2013-03
- Accepted：
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Wei-fang Tong, Xiao-li Liu, Fei Pan, et al. PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES[J]. Chinese Journal of Polymer Science, 2013, 31(3): 495-502.
DOI：

Wei-fang Tong, Xiao-li Liu, Fei Pan, et al. PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES[J]. Chinese Journal of Polymer Science, 2013, 31(3): 495-502. DOI： 10.1007/s10118-013-1210-2.

摘要

Abstract

A method was developed to modify silicon surfaces with good protein resistance and specific cell attachment. A silicon surface was initially deposited using a block copolymer of

-vinylpyrrolidone (NVP) and 2-hydroxyethyl methacrylate (HEMA) (PVP-

-PHEMA) film through surface-initiated atom transfer radical polymerization and then further immobilized using a short arginine-glycine-aspartate (RGD) peptide. Our results demonstrate that the RGD-modified surfaces (Si-RGD) can suppress non-specific adsorption of proteins and induce the adhesion of L929 cells. The Si-RGD surface exhibited higher cell proliferation rates than the unmodified silicon surface. This research established a simple method for the fabrication of dual-functional silicon surface that combines antifouling and cell attachment promotion.

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