MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFT-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

Li-li Xie; Wei-jun Tong; Jian-quan Xu; Chang-you Gao

doi:10.1007/s10118-012-1156-9

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MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFT-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

PAPER | Updated：2023-01-03

- MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFT-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY
- Chinese Journal of Polymer Science Vol. 30, Issue 5, Pages: 719-726(2012)
- Affiliations：
  
  MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  **Wei-jun Tong (仝维鋆), E-mail: tongwj@zju.edu.cn
- Funds：
- DOI：10.1007/s10118-012-1156-9
  CLC：
- Received：07 December 2011，
  
  Revised：2012-01-14，
  
  Accepted：01 February 2012，
  
  Published：2012-09
- Accepted：
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Li-li Xie, Wei-jun Tong, Jian-quan Xu, et al. MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFT-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY[J]. Chinese Journal of Polymer Science, 2012, 30(5): 719-726.
DOI：

Li-li Xie, Wei-jun Tong, Jian-quan Xu, et al. MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-GRAFT-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY[J]. Chinese Journal of Polymer Science, 2012, 30(5): 719-726. DOI： 10.1007/s10118-012-1156-9.

摘要

Abstract

To improve the colloidal stability of bovine serum albumin (BSA) nanoparticles (NPs) in diverse mediums

poly(allylamine hydrochloride) (PAH)/sodium poly(4-styrene sulfonate) (PSS) multilayers and poly(allylamine hydrochloride)-graft-poly(ethylene glycol) (PAH-g-PEG) coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering (DLS). Multilayers and PAH-

-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index (PDI). The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-

-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9

the encapsulation efficiency of doxorubicin reaches almost 99%

and the release rate at pH 5.5 is significantly higher than that at pH 7.4.

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