COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-<italic style="font-style: italic">b</italic>-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS

Chun-yan Long; Ming-ming Sheng; Bin He; Yao Wu; Gang Wang; Zhong-wei Gu

doi:10.1007/s10118-012-1138-y

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COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS

PAPER | Updated：2023-01-03

- COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS
- Chinese Journal of Polymer Science Vol. 30, Issue 3, Pages: 387-396(2012)
- Affiliations：
  
  National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
- Author bio：
  
  **Zhong-wei Gu (顾忠伟), E-mail: zwgu@scu.edu.cn
- Funds：
- DOI：10.1007/s10118-012-1138-y
  CLC：
- Received：17 May 2011，
  
  Revised：2011-08-15，
  
  Accepted：09 September 2011，
  
  Published：2012-05
- Accepted：
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Chun-yan Long, Ming-ming Sheng, Bin He, et al. COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS[J]. Chinese Journal of Polymer Science, 2012, 30(3): 387-396. DOI: 10.1007/s10118-012-1138-y.
DOI：

Chun-yan Long, Ming-ming Sheng, Bin He, et al. COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS[J]. Chinese Journal of Polymer Science, 2012, 30(3): 387-396. DOI: 10.1007/s10118-012-1138-y. DOI：

摘要

Abstract

An anti-tumor drug doxorubicin was encapsulated in micelles of poly(ethylene glycol)-

-poly(2

2-dihydroxylmethyl propylene carbonate) (PEG-

-PDHPC) diblock copolymers. The morphology of both blank micelles and drug loaded micelles was characterized by TEM. The

in vitro

drug release profiles of micelles were investigated. The cytotoxicity of the micelles was evaluated by incubating with Hela tumor cells and 3T3 fibroblasts. The drug loaded micelles were co-cultured with HepG2 cells to evaluate the

in vitro

anti-tumor efficacies. The results showed that the mean sizes of both micelles with different copolymer compositions increased after being loaded with drugs. The drug release rate of PEG

-PDHPC

micelles was faster than that of mPEG

114

-PDHPC

micelles. Both of the two block copolymers were non-toxic. The confocal laser scanning microscopy and flow cytometry results showed that both the drug loaded micelles could be internalized efficiently in HepG2 cells. The PEG

-PDHPC

micelles exhibited higher anti-tumor activity comparing to mPEG

114

-PDHPC

micelles.

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COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS

DOI：10.1007/s10118-012-1138-y

摘要

Abstract

关键词

Keywords

references