POLY(<italic style="font-style: italic">N</italic>-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION

Xiao-li Liu; Zhao-qiang Wu; Dan Li; Hong Chen

doi:10.1007/s10118-012-1118-2

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POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION

PAPER | Updated：2023-01-03

- POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION
- Chinese Journal of Polymer Science Vol. 30, Issue 2, Pages: 235-241(2012)
- Affiliations：
  
  a.School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, China
  b.College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Soochow 215123, China
- Author bio：
  
  **Zhao-qiang Wu (武照强), E-mail: wzqwhu@suda.edu.cn
- Funds：
- DOI：10.1007/s10118-012-1118-2
  CLC：
- Received：25 March 2011，
  
  Revised：2011-05-19，
  
  Accepted：25 May 2011，
  
  Published：2012-03
- Accepted：
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Xiao-li Liu, Zhao-qiang Wu, Dan Li, et al. POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION[J]. Chinese Journal of Polymer Science, 2012, 30(2): 235-241. DOI: 10.1007/s10118-012-1118-2.
DOI：

Xiao-li Liu, Zhao-qiang Wu, Dan Li, et al. POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION[J]. Chinese Journal of Polymer Science, 2012, 30(2): 235-241. DOI: 10.1007/s10118-012-1118-2. DOI：

摘要

Abstract

The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA)

the modified surfaces showed preferential adsorption of HSA. In 100% plasma

the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm

suggesting the excellent protein resistance properties of the modified surfaces. In addition

immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins

especially proteins that play important roles in the process of blood coagulation.

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POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION

DOI：10.1007/s10118-012-1118-2

摘要

Abstract

关键词

Keywords

references