PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATEco-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT

Ya-li Zhang; Xiao-yun Lu; Qian-qian Liu; Ming-chuan Li; Zhi-qian Yang; Jian-gang Ma

doi:10.1007/s10118-012-1095-5

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PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATEco-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT

Paper | Updated：2023-01-03

- PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATEco-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT
- Chinese Journal of Polymer Science Vol. 30, Issue 1, Pages: 101-111(2012)
- Affiliations：
  
  Department of Biological Science and Bioengineering, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
- Author bio：
  
  **Xiao-yun Lu (卢晓云), E-mail: luxy05@mail.xjtu.edu.cn
- Funds：
- DOI：10.1007/s10118-012-1095-5
  CLC：
- Received：14 February 2011，
  
  Revised：2011-04-16，
  
  Accepted：25 April 2011，
  
  Published：2012-01
- Accepted：
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Ya-li Zhang, Xiao-yun Lu, Qian-qian Liu, et al. PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATEco-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT[J]. Chinese Journal of Polymer Science, 2012, 30(1): 101-111.
DOI：

Ya-li Zhang, Xiao-yun Lu, Qian-qian Liu, et al. PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATEco-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT[J]. Chinese Journal of Polymer Science, 2012, 30(1): 101-111. DOI： 10.1007/s10118-012-1095-5.

摘要

Abstract

A novel natural-synthetic hybrid block copolymer was synthesized by

Aeromonas hydrophila

4AK4 in poly(ethylene glycol) (PEG

= 200) modified fermentation. This hybrid biomaterial consists of the natural hydrophobic polymer poly(3-hydroxybutyrat-co-3-hydroxyhexanoate) (PHBHHx) end-capped with hydrophilic PEG

which has the increased flexibility as well as the improved thermal stability. Addition of diethylene glycol (DEG) and ethylene glycol could not result in the accumulation of hybrid block copolymer. DEG and ethylene glycol

together with PEG-200

could cause a reduction of molar mass of PHBHHx

resulting in a series of low molecular weight polymer and the reduction of the polymer yield as well as the cellular productivity.

In vitro

degradation of PHBHH

and PHBHHx-PEG with different molecular weight showed that the decrease of molecular weight accelerated the degradation of copolymers

but PEG modification has little effect on its degradation rate. The results in this study provided a convenient and direct method to produce a series of PHBHHx and PHBHHx-PEG materials with adjustable molecular weight and broad molecular weight distribution which will be very useful for the biomedical applications.

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