FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-<italic style="font-style: italic">b</italic>-PEG MICELLES FOR TUMOR IMAGING

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FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING

RAPID COMMUNICATION | Updated：2021-06-21

- FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING
- Chinese Journal of Polymer Science Vol. 29, Issue 4, Pages: 427-430(2011)
- Affiliations：
  
  Center for Bionanoengineering and the State Key Laboratory for Chemical Engineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  **Jian-bin Tang (唐建斌), E-mail: jianbin@zju.edu.cn
- Funds：
- DOI：10.1007/s10118-011-1057-3
  CLC：
- Received：25 March 2011，
  
  Revised：2011-04-21，
  
  Accepted：25 April 2011，
  
  Published：2011
- Accepted：
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Xiao-ming Sun, Jin-xia Xu, Jian-bin Tang, et al. FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING[J]. Chinese Journal of Polymer Science, 2011, 29(4): 427-430. DOI: 10.1007/s10118-011-1057-3.
DOI：

Xiao-ming Sun, Jin-xia Xu, Jian-bin Tang, et al. FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING[J]. Chinese Journal of Polymer Science, 2011, 29(4): 427-430. DOI: 10.1007/s10118-011-1057-3. DOI：

摘要

Abstract

A biodegradable tumor targeting nano-probe based on poly(

ε

-caprolactone)-

b

-poly(ethylene glycol) block copolymer (PCL-

b

-PEG) micelle functionalized with a magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid-gadolinium (DTPA-Gd

3+

) on the shell and a near-infrared (NIR) dye in the core for magnetic resonance and optical dual-modality imaging was prepared. The longitudinal relaxivity (r

1

) of the PCL-

b

-PEG-DTPA- Gd

3+

micelle was 13.4 (mmol/L)

-1

s

-1

three folds of that of DTPA-Gd

3+

and higher than that of many polymeric contrast agents with similar structures. The

in vivo

optical imaging of a nude mouse bearing xenografted breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor

via

the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention (EPR) effect. The results indicated that the dual-modality micelle is a promising nano-probe for cancer detection and diagnosis.

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