BINDING OF THERMO-SENSITIVE AND pH-SENSITIVE BUTYLATED POLY(ALLYLAMINE)S WITH LYSOZYME

Jing-jing Liu; Yun-feng Yan; Ping Yao

doi:10.1007/s10118-011-1054-6

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BINDING OF THERMO-SENSITIVE AND pH-SENSITIVE BUTYLATED POLY(ALLYLAMINE)S WITH LYSOZYME

Special Issue: The 8th International Symposium on Polyelectrolytes (ISP 2010) | Updated：2021-06-21

- BINDING OF THERMO-SENSITIVE AND pH-SENSITIVE BUTYLATED POLY(ALLYLAMINE)S WITH LYSOZYME
- Chinese Journal of Polymer Science Vol. 29, Issue 4, Pages: 397-406(2011)
- Affiliations：
  
  Key Laboratory of Molecular Engineering of Polymer and Department of Macromolecular Science, Fudan University, Shanghai 200433, China
- Author bio：
  
  **Ping Yao (姚萍), E-mail: yaoping@fudan.edu.cn
- Funds：
- DOI：10.1007/s10118-011-1054-6
  CLC：
- Received：27 December 2010，
  
  Revised：2011-03-08，
  
  Accepted：11 March 2011，
  
  Published：2011
- Accepted：
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Jing-jing Liu, Yun-feng Yan, Ping Yao. BINDING OF THERMO-SENSITIVE AND pH-SENSITIVE BUTYLATED POLY(ALLYLAMINE)S WITH LYSOZYME[J]. Chinese Journal of Polymer Science, 2011, 29(4): 397-406.
DOI：

Jing-jing Liu, Yun-feng Yan, Ping Yao. BINDING OF THERMO-SENSITIVE AND pH-SENSITIVE BUTYLATED POLY(ALLYLAMINE)S WITH LYSOZYME[J]. Chinese Journal of Polymer Science, 2011, 29(4): 397-406. DOI： 10.1007/s10118-011-1054-6.

摘要

Abstract

Butyl modified poly(allylamine)s with butyl substitution degrees of 15% to 70% were prepared. The polymers show pH sensitive property and lower critical solution temperature (LCST) behavior. The LCST appears at lower temperature

lower pH and lower polymer concentration for the polymer with higher butylated degree. The binding of native lysozyme with the polymers depends on the hydrophobicity of the polymers at the pH range that the protein and the polymer carry the same positive charges. The increase of polymer hydrophobicity can increase the binding with lysozyme

but the self-aggregation of the polymer decreases the binding. The bound lysozyme molecules can recover their native activity completely after the dissociation of the complexes. Compared with native lysozyme

the denatured one which exposes the hydrophobic residues can increase the binding with the polymer and form stable complex nanoparticles.

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