WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS

Chun-hong Xu; Mei-hua Sui; Jian-bin Tang; You-qing Shen

doi:10.1007/s10118-011-1047-5

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WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS

Review | Updated：2021-06-21

- WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS
- Chinese Journal of Polymer Science Vol. 29, Issue 3, Pages: 274-287(2011)
- Affiliations：
  
  Center for Bionanoengineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
- Author bio：
  
  **You-qing Shen (申有青), E-mail: shenyq@zju.edu.cn
- Funds：
- DOI：10.1007/s10118-011-1047-5
  CLC：
- Received：21 February 2011，
  
  Revised：2011-03-07，
  
  Accepted：09 March 2011，
  
  Published：2011
- Accepted：
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Chun-hong Xu, Mei-hua Sui, Jian-bin Tang, et al. WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS[J]. Chinese Journal of Polymer Science, 2011, 29(3): 274-287.
DOI：

Chun-hong Xu, Mei-hua Sui, Jian-bin Tang, et al. WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS[J]. Chinese Journal of Polymer Science, 2011, 29(3): 274-287. DOI： 10.1007/s10118-011-1047-5.

摘要

Abstract

Gene therapy has emerged as a potential new approach to treat genetic disorders by delivering therapeutic genes to target diseased tissues. However

its clinical use has been impeded by gene delivery systems. The viral vectors are very efficient in delivering and expressing their carried genes

but they have safety issues in clinical use. While nonviral vectors are much safer with very low risks after careful material design

but their gene transcription efficiency is too low to be clinically used. Thus

rational design of nonviral vectors mimicking the viral vectors would be a way to break this bottleneck. This review compares side-by-side how viral/nonviral gene vectors transcend these biological barriers in terms of blood circulation

cellular uptake

endosome escape

nucleus import and gene transcription.

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