CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)

Yi-jie Liu; Hong-liang Jiang; Yan Li; Kang-jie Zhu

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CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)

Papers | Updated：2021-06-21

- CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)
- Vol. 26, Issue 1, Pages: 63-71(2008)
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- Published：20 January 2008
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Yi-jie Liu, Hong-liang Jiang, Yan Li, et al. CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)[J]. 2008, 26(1): 63-71.
DOI：

Yi-jie Liu, Hong-liang Jiang, Yan Li, et al. CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)[J]. 2008, 26(1): 63-71. DOI：

摘要

The purpose of this study is to investigate the effect of composition poly(D

L-lactide-co-glycolide)/poly(#61541;-caprolactone) (PLGA/PCL) blending on the morphology

shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers

the average diameter of the electrospun fibers increased from 1.35 μm to 1.95μm. The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers

resulting from the semi-crystalline nature of PCL. The degradation rate of the electrospun meshes could be modulated by PLGA/PCL composition. In addition

the electrospun meshes containing 20% PCL displayed stable dimensional morphology with degradation.

Abstract

The purpose of this study is to investigate the effect of composition poly(D

L-lactide-co-glycolide)/poly(#61541;-caprolactone) (PLGA/PCL) blending on the morphology

shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers

the average diameter of the electrospun fibers increased from 1.35 μm to 1.95μm. The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers

resulting from the semi-crystalline nature of PCL. The degradation rate of the electrospun meshes could be modulated by PLGA/PCL composition. In addition

the electrospun meshes containing 20% PCL displayed stable dimensional morphology with degradation.

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