MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS&#8722;&#8722;A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES

Jun Zhou; Yong-zhi Qiu; Xiao-peng Zang; Chang-wang Pan; Qiang Chen; Jian Shen; Si-cong Lin

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MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES

Papers | Updated：2021-06-21

- MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES
- Vol. 23, Issue 1, Pages: 93-102(2005)
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- Published：20 January 2005
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Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, et al. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 2005, 23(1): 93-102.
DOI：

Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, et al. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. 2005, 23(1): 93-102. DOI：

摘要

N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane)(SPEU)and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR

XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro

the two materials studied

including poly-DMMCA gel

all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.

Abstract

XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro

the two materials studied

including poly-DMMCA gel

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MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES

DOI：

摘要

Abstract

关键词

Keywords

references