THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINED POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS CROSS-LINKED BY Si―O―Si BONDS

Jian-tao Zhang; Shi-wen Huang; Ya-nan Xue; Ji Liu; Ren-xi Zhuo

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THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINED POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS CROSS-LINKED BY Si―O―Si BONDS

Papers | Updated：2021-06-21

- THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINED POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS CROSS-LINKED BY Si―O―Si BONDS
- Vol. 23, Issue 5, Pages: 513-519(2005)
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- Published：20 September 2005
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Jian-tao Zhang, Shi-wen Huang, Ya-nan Xue, et al. THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINED POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS CROSS-LINKED BY Si―O―Si BONDS[J]. 2005, 23(5): 513-519.
DOI：

Jian-tao Zhang, Shi-wen Huang, Ya-nan Xue, et al. THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINED POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS CROSS-LINKED BY Si―O―Si BONDS[J]. 2005, 23(5): 513-519. DOI：

摘要

A series of novel p(N-isopropylacrylamide) (PNIPAM) hydrogels were synthesized by radical copolymerization of N-isopropylacrylamide (NIPAM) and 3-methacryloxypropyltrimethoxysilane (MPTMS). The copolymers were then crosslinked through hydrolysis of the siloxane in acetic acid/water mixed solvent. Beta-cyclodextrin (Beta-CD) was introduced into the polymeric networks by condensation of 3-glycidoxypropyltrimethoxysilane derived beta-cyclodextrin (KH560-beta-CD) with MPTMS under acidic condition. These gels were heterogeneous

porous and exhibited fast deswelling kinetics when the temperature was elevated to above lower critical solution temperature (LCST). The swelling ratios of the gels containing beta-CD at room temperature were higher than that of the normal PNIPAM hydrogel

which was caused by the lower crosslinking density in beta-CD contained gels. In comparison to that of the normal PNIPAM gel

the amount of loaded-drug in the hydrogel containing beta-CD was higher

and the release time of 5-fluorouracil (5-Fu) was prolonged

which was attributed to the formation of inclusion compounds between 5-Fu and beta-CD in gel network.

Abstract

which was caused by the lower crosslinking density in beta-CD contained gels. In comparison to that of the normal PNIPAM gel

the amount of loaded-drug in the hydrogel containing beta-CD was higher

and the release time of 5-fluorouracil (5-Fu) was prolonged

which was attributed to the formation of inclusion compounds between 5-Fu and beta-CD in gel network.

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