Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine

Jun Zhu; Chang-wang Pan; Ling Tong; Han Yan; Jian Shen; Si-cong Lin

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Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine

Note | Updated：2021-06-21

- Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine
- Vol. 23, Issue 4, Pages: 449-452(2005)
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- Published：20 July 2005
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Jun Zhu, Chang-wang Pan, Ling Tong, et al. Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine[J]. 2005, 23(4): 449-452.
DOI：

Jun Zhu, Chang-wang Pan, Ling Tong, et al. Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine[J]. 2005, 23(4): 449-452. DOI：

摘要

In order to improve the nonthrombogenicity of chitin

a new monomer

N-dimethyl(b-hydroxyethyloxyethyl) ammonium propanesulfonate (DHAPS) was designed

synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate (HDI) as a coupling agent. Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface. The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method. The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved.

Abstract

In order to improve the nonthrombogenicity of chitin

a new monomer

N-dimethyl(b-hydroxyethyloxyethyl) ammonium propanesulfonate (DHAPS) was designed

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