GRAFTING OF HYDROPHILIC MONOMERS ONTO POLYURETHANE MEMBRANES BY SOLUTION OR PRE-ABSORBING METHODS FOR ACCELERATION OF CELL COMPATIBILITY*

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GRAFTING OF HYDROPHILIC MONOMERS ONTO POLYURETHANE MEMBRANES BY SOLUTION OR PRE-ABSORBING METHODS FOR ACCELERATION OF CELL COMPATIBILITY*

Papers | Updated：2021-06-21

- GRAFTING OF HYDROPHILIC MONOMERS ONTO POLYURETHANE MEMBRANES BY SOLUTION OR PRE-ABSORBING METHODS FOR ACCELERATION OF CELL COMPATIBILITY*
- Vol. 19, Issue 5, Pages: 493-498(2001)
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- Published：20 October 2001
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GRAFTING OF HYDROPHILIC MONOMERS ONTO POLYURETHANE MEMBRANES BY SOLUTION OR PRE-ABSORBING METHODS FOR ACCELERATION OF CELL COMPATIBILITY*[J]. 2001, 19(5): 493-498.
DOI：

GRAFTING OF HYDROPHILIC MONOMERS ONTO POLYURETHANE MEMBRANES BY SOLUTION OR PRE-ABSORBING METHODS FOR ACCELERATION OF CELL COMPATIBILITY*[J]. 2001, 19(5): 493-498. DOI：

摘要

Two grafting methods

i.e. solution grafting and pre-adsorbing

are introduced to covalently immobilizehydrophilic polymers on segmented polyurethane (SPU) to modify its hydrophilicity and to improve its cell compatibility.Solution grafting results in higher degree of grafting and rougher surface morphology. Cell culture evaluation demonstratesthat the modified membranes thus obtained are disadvantageous to the endothelial cell (ECs) growth probably because thehydrophilic groups on the surface are over-crowded.However

pre-absorbing grafting generates lower degree of grafting

which is detected and confirmed by ATR-FTIR spectra and water contact angle.Scanning electron microscopic (SEM) measurement shows that the latter method produces a plane and smooth morphology

which is similar to the SPU control sample controlled.When grafting with lower monomer concentration

ECs could grow on SPU-g-PHEA [poly(2-hydroxyethyl acrylate)]

SPU-g-PAAm(polyacrylamide)

SPU-g-PDMA[poly(2-(dimethylamino)ethyl methacrylate)] or quaternized SPU-g-PDMA surface with elongated cell shapes.Hence

the cell compatibility of SPU is improved and a useful method to construct a cell compatible layer on the polymer surface has been developed.

Abstract

Two grafting methods

i.e. solution grafting and pre-adsorbing

pre-absorbing grafting generates lower degree of grafting

which is detected and confirmed by ATR-FTIR spectra and water contact angle.Scanning electron microscopic (SEM) measurement shows that the latter method produces a plane and smooth morphology

which is similar to the SPU control sample controlled.When grafting with lower monomer concentration

ECs could grow on SPU-g-PHEA [poly(2-hydroxyethyl acrylate)]

SPU-g-PAAm(polyacrylamide)

SPU-g-PDMA[poly(2-(dimethylamino)ethyl methacrylate)] or quaternized SPU-g-PDMA surface with elongated cell shapes.Hence

the cell compatibility of SPU is improved and a useful method to construct a cell compatible layer on the polymer surface has been developed.

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