RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*

Your Location：

Home >

Browse articles >

RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*

Papers | Updated：2021-06-21

- RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*
- Vol. 17, Issue 3, Pages: 265-270(1999)
- Affiliations：
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：20 June 1999
- Accepted：
Scan QR Code
RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*[J]. 1999, 17(3): 265-270.
DOI：

RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*[J]. 1999, 17(3): 265-270. DOI：

摘要

Poly-dl -lactide-poly(ethylene glycol ) (PELA) triblock copolymers were synthesized withlanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outermembrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods.The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0μm

which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues

such as the liver

spleen and intestinal peyer's patches

following oral administration.The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.

Abstract

such as the liver

spleen and intestinal peyer's patches

following oral administration.The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Preparation and Chiral Recognition Ability of Crystalline Cellulose Phenylcarbamate

Sliding Dynamics of Ring Chain on a Rod-Coil Block Copolymer in Rotaxane

Highly Regio- and trans-Selective Ring-opening Metathesis Polymerization of Chiral Aza-norbornene with a Simple Phenylimido-Tungsten Catalyst

Molecular Segregation and Melt Memory in Dilute Polycaprolactone with Reduced Entanglements

From Molecular Defect to Macroscopic Performance: Manipulating Dichroism and Mechanics in Iodine-doped Poly(vinyl alcohol) via Ethylene Incorporation

Related Author

No data

Related Institution

No data

⁰