INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*

DING Qiong; ZHANG Lina; ZENG Fanbo

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INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*

Papers | Updated：2021-06-21

- INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*
- Vol. 16, Issue 1, Pages: 62-66(1998)
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- Published：20 March 1998
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DING Qiong, ZHANG Lina, ZENG Fanbo. INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*[J]. 1998, 16(1): 62-66.
DOI：

DING Qiong, ZHANG Lina, ZENG Fanbo. INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*[J]. 1998, 16(1): 62-66. DOI：

摘要

In this work

influence of molecular weight and periodate modification ofβ-D-glucans isolated from Poria cocos sclerotium on the antitumor activities against Sar-coma 180 and Ehrlich ascites carcinoma (EAC) tumor was studied. The results show thattwo glucans PC3 (linear β-(1→3)-D-glucan) and PC4 [β-(1→3)-D-glucan with a fewof branches and glucuronic acid] are devoid of antitumor activity. However

when theglucans were modified by periodate oxidation

borohydride reduction and mild hydrolysis or partially hydrolysis

the derivatives have obvious antitumor activities.The decrease in molecular weight of glucans after periodate modification hardly affects their antitumor actions

but on the other hand

the decrease of molecular weight without periodate modification could lead to an enhancement of the antitumor activities.Moreover

the glucans and these derivatives have much higher enhancement ratios of body weight of mice than that of --Fluorouracil (5-Fu)

suggesting that they are less toxic than 5-Fu.

Abstract

In this work

when theglucans were modified by periodate oxidation

borohydride reduction and mild hydrolysis or partially hydrolysis

the derivatives have obvious antitumor activities.The decrease in molecular weight of glucans after periodate modification hardly affects their antitumor actions

but on the other hand

the decrease of molecular weight without periodate modification could lead to an enhancement of the antitumor activities.Moreover

the glucans and these derivatives have much higher enhancement ratios of body weight of mice than that of --Fluorouracil (5-Fu)

suggesting that they are less toxic than 5-Fu.

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