UNIQUE ORAL DRUG DELIVERY SYSTEM

Raphael M.Ottenbrite; Sam Milstein

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UNIQUE ORAL DRUG DELIVERY SYSTEM

Papers | Updated：2021-06-21

- UNIQUE ORAL DRUG DELIVERY SYSTEM
- Vol. 13, Issue 4, Pages: 315-321(1995)
- Affiliations：
  
  1. Sam Milstein Chemistry Department, Virginia Commonwealth University, Richmond, VA 23284-2006, USA Emisphere Technologies Inc., 15 Skyline Drive Hawthorne,NY,USA,10595
  2.   Virginia Commonwealth University
  3.   Richmond
  4.   VA   ,23284-2006
  5.   USA
  6.   Emisphere Technologies Inc.
  7.   15 Skyline Drive Hawthorne
  8.   NY 10595
- Author bio：
- Funds：
- DOI：
  CLC： O629.73
- Published：20 December 1995
- Accepted：
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[1]Raphael M.Ottenbrite,Sam Milstein.UNIQUE ORAL DRUG DELIVERY SYSTEM[J].Chinese Journal of Polymer Science,1995,{4}(04):315-321.

Raphael M.Ottenbrite, Sam Milstein. UNIQUE ORAL DRUG DELIVERY SYSTEM[J]. 1995, 13(4): 315-321.
[1]Raphael M.Ottenbrite,Sam Milstein.UNIQUE ORAL DRUG DELIVERY SYSTEM[J].Chinese Journal of Polymer Science,1995,{4}(04):315-321. DOI：

Raphael M.Ottenbrite, Sam Milstein. UNIQUE ORAL DRUG DELIVERY SYSTEM[J]. 1995, 13(4): 315-321. DOI：

摘要

<正> An oral drug delivery system using proteinoid microspheres is discussed with respect to itsunique dependence on pH. It has been found that certain drugs such as insulin and heparin canbe encapsulated in proteinoid spheres at stomach pH’s （1--3）. These spheres also dissemble atintestinal pH’s （6--7） releasing the drug for absorption. Using this technique low molecularweight heparin and human growth hormone have been orally delivered successfully to severalanimal species. Future work has been proposed to study the interaction and binding of thespecific drugs with synthesized oligopeptides.

Abstract

An oral drug delivery system using proteinoid microspheres is discussed with respect to itsunique dependence on pH. It has been found that certain drugs such as insulin and heparin canbe encapsulated in proteinoid spheres at stomach pH’s （1--3）. These spheres also dissemble atintestinal pH’s （6--7） releasing the drug for absorption. Using this technique low molecularweight heparin and human growth hormone have been orally delivered successfully to severalanimal species. Future work has been proposed to study the interaction and binding of thespecific drugs with synthesized oligopeptides.

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