POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR

BEI Jianzhong; WANG Zhifeng; WANG Shenguo

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POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR

Papers | Updated：2021-06-21

- POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR
- Vol. 13, Issue 2, Pages: 154-161(1995)
- Affiliations：
  
  1.   Institute of Chemistry
  2.   Academia Sinica
  3.   Beijing 100080
- Author bio：
- Funds：
- DOI：
  CLC： O631.5
- Published：20 June 1995
- Accepted：
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[1]贝建中,王智峰,王身国.POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR[J].Chinese Journal of Polymer Science,1995,{4}(02):154-161.

BEI Jianzhong, WANG Zhifeng, WANG Shenguo. POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR[J]. 1995, 13(2): 154-161.
[1]贝建中,王智峰,王身国.POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR[J].Chinese Journal of Polymer Science,1995,{4}(02):154-161. DOI：

BEI Jianzhong, WANG Zhifeng, WANG Shenguo. POLYCAPROLACTONE-POLY (ETHYLENE GLYCOL) BLOCK COPOLYMER Ⅲ DRUG RELEASE BEHAVIOR[J]. 1995, 13(2): 154-161. DOI：

摘要

<正> The drug release behavior of degradable polymer--polycaprolactone-poly （ethyleneglycol）block copolymer（PCE） in vitro was investigated by using 5-Fluoro-uracil （5-Fu） asa model drug under a condition of pH 7. 4 at 37C. It is found that the release rate of 5-Fufrom PCE increased with increasing polyether content of the copolymer. The results showthat the increasing polyether content of the copolymer caused increasing hydrophilicity anddecreasing crystallinity of the PCE copolymer. Thus

the drug release behavior and thedegradable property of the PCE can be controlled by adjusting the composition of thecopolymer.

Abstract

The drug release behavior of degradable polymer--polycaprolactone-poly （ethyleneglycol）block copolymer（PCE） in vitro was investigated by using 5-Fluoro-uracil （5-Fu） asa model drug under a condition of pH 7. 4 at 37C. It is found that the release rate of 5-Fufrom PCE increased with increasing polyether content of the copolymer. The results showthat the increasing polyether content of the copolymer caused increasing hydrophilicity anddecreasing crystallinity of the PCE copolymer. Thus

the drug release behavior and thedegradable property of the PCE can be controlled by adjusting the composition of thecopolymer.

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