CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER

ZHUO Renxi; LIU Zhenghua; Li Li

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CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER

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- CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER
- Vol. 7, Issue 2, Pages: 179-182(1989)
- Affiliations：
  
  1. Department of Chemistry, Wuhan University,Wuhan
  2. Wuhan University
  3. Wuhan
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：20 June 1989
- Accepted：
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[1]卓仁禧,刘振华,李立.CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER[J].Chinese Journal of Polymer Science,1989,{4}(02):179-182.

ZHUO Renxi, LIU Zhenghua, Li Li. CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER[J]. 1989, 7(2): 179-182.
[1]卓仁禧,刘振华,李立.CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER[J].Chinese Journal of Polymer Science,1989,{4}(02):179-182. DOI：

ZHUO Renxi, LIU Zhenghua, Li Li. CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER[J]. 1989, 7(2): 179-182. DOI：

摘要

<正> Eight new polyphosphates containing both nucleic acid base and phosphonoacetic acid ethyl ester were synthesized by the polycondensation of P

P-dichloride of phosphonoacetic acid ethyl ester with 1

3-dihydroxyalkyl-5-fluorouracil

3-dihydroxyalkyl-uracil and 1

3-dihydroxyalkylthymine. These polyphosphates were tested against Ehrlich Ascites Carcinoma in mice. Polymer IIa and IIc exhibited excellent antitumor activity. IIc also showed lower toxicity.

Abstract

Eight new polyphosphates containing both nucleic acid base and phosphonoacetic acid ethyl ester were synthesized by the polycondensation of P

P-dichloride of phosphonoacetic acid ethyl ester with 1

3-dihydroxyalkyl-5-fluorouracil

3-dihydroxyalkyl-uracil and 1

3-dihydroxyalkylthymine. These polyphosphates were tested against Ehrlich Ascites Carcinoma in mice. Polymer IIa and IIc exhibited excellent antitumor activity. IIc also showed lower toxicity.

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