CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP
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CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP
Vol. 4, Issue 2, Pages: 165-169(1986)
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Published:20 June 1986
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ZHUO Renxi, FAN Changlie, MAI Caison, et al. CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP[J]. 1986, 4(2): 165-169.
DOI:
ZHUO Renxi, FAN Changlie, MAI Caison, et al. CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP[J]. 1986, 4(2): 165-169.DOI:
CHEMOTHERAPEUTIC POLYMERS Ⅻ. SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYAMIDES CONTAINING 5-FLUOROURACILS AS PENDANT GROUP
Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR
UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice
IIIa showed an inhibitionrate of 43%.
Abstract
Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR
UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice
IIIa showed an inhibitionrate of 43%.
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