SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL

PIAO Aichih; SUN Shumen

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SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL

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- SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL
- Vol. 1, Issue 2, Pages: 196-199(1983)
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- Published：20 November 1983
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PIAO Aichih, SUN Shumen. SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL[J]. 1983, 1(2): 196-199.
DOI：

PIAO Aichih, SUN Shumen. SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL[J]. 1983, 1(2): 196-199. DOI：

摘要

The condensation oligomers of 5-fluorouracil were prepared by reaction of 2

4-bis-(trimethyl-silyloxy)-5-fluoropyrimidine) with various dicarboxylic chlorides

e.g.The structures of obtained oligomers were characterized by IR and the oligomers were then hydrolyzed in acid

alkaline and neutral media at room temperature respectively. The amount of 5-fluorouracil released was quantitated by measuring its UV absorbance at 265.5nm. However in the case of oligomers containing phenylene moiety

5-fluorouracil was not detected when the hydrolysis was conducted in acid or neutral medium

while in the case of oligomers containing methylene moiety

hydrolysis proceeded easily in acid

alkaline and neutral media.

Abstract

The condensation oligomers of 5-fluorouracil were prepared by reaction of 2

4-bis-(trimethyl-silyloxy)-5-fluoropyrimidine) with various dicarboxylic chlorides

e.g.The structures of obtained oligomers were characterized by IR and the oligomers were then hydrolyzed in acid

5-fluorouracil was not detected when the hydrolysis was conducted in acid or neutral medium

while in the case of oligomers containing methylene moiety

hydrolysis proceeded easily in acid

alkaline and neutral media.

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