SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo

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SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo

Papers | Updated：2021-06-21

- SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo
- Vol. 27, Issue 2, Pages: 231-239(2009)
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- Published：20 March 2009
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SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo[J]. 2009, 27(2): 231-239.
DOI：

SURFACE MULTI-FUNCTIONALIZATION OF POLY(LACTIC ACID) NANOPARTICLES AND C6 GLIOMA CELL TARGETING in vivo[J]. 2009, 27(2): 231-239. DOI：

摘要

Polysaccharide coated PLA nanoparticles bearing aldehyde groups were prepared by dialysis of DMSO solution of cholesterol hydrophobic-modified dextran polyaldehyde and PLA against water. The average diameter of the nanoparticles was about 160 nm

and the size distribution was nearly homogenous. The nanoparticles were functionalized simultaneously with CD71 and EGFR antibody through the Schiff’s base reaction

and then radiolabeled with 99mTc. After perfused the radiolabeled nanoparticles into tumor-bearing rats through left common carotid artery

the radioactivity in liver

spleen

kidney and brain was measured by scintillation counter. The results showed that less than 2% of nanoparticles were uptaken by the brain due to the uptake of the nanoparticles by the RES system. However

the coupling of transferrin antibody on the nanoparticles facilitated the penetration of nanoparticles across the blood brain barrier

and more specially

compared with monofuctionalized and native nanoparticles

the multifunctionalization enhanced the tumor accumulation of the nanoparticles in vivo.

Abstract

and the size distribution was nearly homogenous. The nanoparticles were functionalized simultaneously with CD71 and EGFR antibody through the Schiff’s base reaction

and then radiolabeled with 99mTc. After perfused the radiolabeled nanoparticles into tumor-bearing rats through left common carotid artery

the radioactivity in liver

spleen

the coupling of transferrin antibody on the nanoparticles facilitated the penetration of nanoparticles across the blood brain barrier

and more specially

compared with monofuctionalized and native nanoparticles

the multifunctionalization enhanced the tumor accumulation of the nanoparticles in vivo.

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