Cryo-induced Encapsulation of Amino-functionalized Zeolitic Imidazolate Framework-8 Microspheres within Biomass-based Cryogel Walls for Effective Hemoperfusion

Pei-Rong Jiang; Xu-Feng Zhang; Ji-Ping Weng; Yan Liu; Jin Huang; Xiang-Yu Chen; Jing Shen; Xi-Yun Feng; Liang-Fei Duan; Jun Wang

doi:10.1007/s10118-026-3880-6

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Cryo-induced Encapsulation of Amino-functionalized Zeolitic Imidazolate Framework-8 Microspheres within Biomass-based Cryogel Walls for Effective Hemoperfusion

RESEARCH ARTICLE | Updated：2026-11-09

- Cryo-induced Encapsulation of Amino-functionalized Zeolitic Imidazolate Framework-8 Microspheres within Biomass-based Cryogel Walls for Effective Hemoperfusion
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-14(2026)
- Affiliations：
  
  a.Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
  b.School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China
  c.Emergency Department, Southwest Hospital of Army Medical University, Chongqing 400038, China
- Author bio：
  
  xfzhang@ynnu.edu.cn (X.F.Z.)
  huangjin@iccas.ac.cn (J.H.)
  xiangyuchen@tmmu.edu.cn (X.Y.C.)
  shenjing@ynnu.edu.cn (J.S.)
- Funds：
- DOI：10.1007/s10118-026-3880-6
  CLC：
- Received：07 July 2026，
  
  Accepted：07 September 2026，
  
  Online First：09 November 2026，
  
  Published：2026-10
- Accepted：
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Jiang, P. R.; Zhang, X. F.; Weng, J. P.; Liu, Y.; Huang, J.; Chen, X. Y.; Shen, J.; Feng, X. Y.; Duan, L. F.; Wang, J. Cryo-induced encapsulation of amino-functionalized zeolitic imidazolate framework-8 microspheres within biomass-based cryogel walls for effective hemoperfusion. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3880-6

Pei-Rong Jiang, Xu-Feng Zhang, Ji-Ping Weng, et al. Cryo-induced Encapsulation of Amino-functionalized Zeolitic Imidazolate Framework-8 Microspheres within Biomass-based Cryogel Walls for Effective Hemoperfusion[J/OL]. Chinese Journal of Polymer Science, 2026, 441-14.
Jiang, P. R.; Zhang, X. F.; Weng, J. P.; Liu, Y.; Huang, J.; Chen, X. Y.; Shen, J.; Feng, X. Y.; Duan, L. F.; Wang, J. Cryo-induced encapsulation of amino-functionalized zeolitic imidazolate framework-8 microspheres within biomass-based cryogel walls for effective hemoperfusion. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3880-6 DOI：

Pei-Rong Jiang, Xu-Feng Zhang, Ji-Ping Weng, et al. Cryo-induced Encapsulation of Amino-functionalized Zeolitic Imidazolate Framework-8 Microspheres within Biomass-based Cryogel Walls for Effective Hemoperfusion[J/OL]. Chinese Journal of Polymer Science, 2026, 441-14. DOI： 10.1007/s10118-026-3880-6.

摘要

Abstract

Efficient removal of protein-bound toxins remains a formidable challenge in artificial liver support systems because of the persistent trade-off between adsorption capacity and hemocompatibility. In this study

a wall-integrated cryogel was developed by embedding amino-functionalized zeolitic imidazolate framework-8 (mZIF-8) within a biomass matrix of quaternized chitosan (QCS) and microfibrillated cellulose (MFC) using a green cryo-induced assembly process. During freezing

the mZIF-8 nanoparticles were concentrated in the polymer-rich interstitial regions and assembled into microspheres that became confined within the cryogel walls

resulting in a microsphere-in-wall architecture. The optimized mZIF-8@QCS/MFC cryogel showed a bilirubin saturation capacity of 146.6 mg/g in albumin-containing solution. Spectroscopic analysis suggested that bilirubin capture involved the combined contribution of electrostatic attraction from the positively charged polysaccharide matrix and the hydrogen bonding provided by mZIF-8. The hydrophilic biomass walls reduced the direct exposure of mZIF-8 to the external environment and limited nonspecific albumin adsorption. The composite cryogel exhibited a hemolysis ratio of 0.4% and stable performance under continuous-flow conditions. These results show that spatial regulation of metal-organic frameworks (MOFs) locations within carbohydrate cryogel walls may provide a useful strategy for balancing adsorption accessibility and blood-contacting compatibility in the design of bilirubin adsorbents.

关键词

Keywords

references

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