Engineering Elastin-like Polypeptide Hydrogels: from Design Strategies to Cellular and Biomedical Applications

Li-Yang Zhu; Wen Sun; Rui-Qing Wang; Bin Xue; Yi Cao

doi:10.1007/s10118-026-3848-6

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Engineering Elastin-like Polypeptide Hydrogels: from Design Strategies to Cellular and Biomedical Applications

REVIEW | Updated：2026-10-19

- Engineering Elastin-like Polypeptide Hydrogels: from Design Strategies to Cellular and Biomedical Applications
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-24(2026)
- Affiliations：
  
  a.Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, School of Physics, Nanjing University, Nanjing 210093, China
  b.Chemistry and Biomedicine Innovation Center, School of Chemistry, Nanjing University, Nanjing 210093, China
  c.MOE Key Laboratory of High Performance Polymer Materials & Technology, Nanjing University, Nanjing 210023, China
- Author bio：
  
  xuebinnju@nju.edu.cn (B.X.)
  caoyi@nju.edu.cn (Y.C.)
- Funds：
- DOI：10.1007/s10118-026-3848-6
  CLC：
- Received：12 July 2026，
  
  Accepted：15 August 2026，
  
  Online First：19 October 2026，
  
  Published：2026-09
- Accepted：
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Zhu, L. Y.; Sun, W.; Wang, R. Q.; Xue, B.; Cao, Y. Engineering elastin-like polypeptide hydrogels: from design strategies to cellular and biomedical applications. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3848-6

Li-Yang Zhu, Wen Sun, Rui-Qing Wang, et al. Engineering Elastin-like Polypeptide Hydrogels: from Design Strategies to Cellular and Biomedical Applications[J/OL]. Chinese Journal of Polymer Science, 2026, 441-24.
Zhu, L. Y.; Sun, W.; Wang, R. Q.; Xue, B.; Cao, Y. Engineering elastin-like polypeptide hydrogels: from design strategies to cellular and biomedical applications. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3848-6 DOI：

Li-Yang Zhu, Wen Sun, Rui-Qing Wang, et al. Engineering Elastin-like Polypeptide Hydrogels: from Design Strategies to Cellular and Biomedical Applications[J/OL]. Chinese Journal of Polymer Science, 2026, 441-24. DOI： 10.1007/s10118-026-3848-6.

摘要

Abstract

Elastin-like polypeptide (ELP) hydrogels are a class of biomaterials precisely encoded through genetic engineering. Owing to their excellent biocompatibility

precisely tunable thermoresponsive behavior

and favorable biodegradability

they hold great promise in the biomedical field. This review systematically summarizes the core design strategies of ELP hydrogels and their associated advances in cellular and biomedical applications. The discussion begins with an overview of the diverse physicochemical crosslinking strategies underlying the formation of ELP hydrogel networks. It then highlights the design of biomimetic extracellular matrices through the integration of functional domains. This approach promotes the application of ELP hydrogels in 3D cell culture and tissue engineering

such as cartilage and vascular regeneration. The review further examines applied research in cutting-edge fields

such as drug delivery

elucidating how the integration of material properties with biological functions can provide innovative solutions for complex tissue repair and regenerative medicine. Finally

this review offers a systematic theoretical reference and design rationale by discussing the future development of integrated ELP-based biomaterial platforms with dynamic

intelligent responsiveness and multifunctional domain capabilities.

关键词

Keywords

references

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