A Water-soluble NIR-II Polyzwitterionic Aza Boron Dipyrromethene Probe with Prolonged Blood Circulation for High-contrast Vascular Imaging

Ju-Li Duan; Xue Shuai; Tian Chen; Sheng-Yu Shi; Yong Fan; Kuo Jia; Chen-Zhi Yao

doi:10.1007/s10118-026-3797-0

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A Water-soluble NIR-II Polyzwitterionic Aza Boron Dipyrromethene Probe with Prolonged Blood Circulation for High-contrast Vascular Imaging

RESEARCH ARTICLE | Updated：2026-10-23

- A Water-soluble NIR-II Polyzwitterionic Aza Boron Dipyrromethene Probe with Prolonged Blood Circulation for High-contrast Vascular Imaging
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-10(2026)
- Affiliations：
  
  a.Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China
  b.State Key Laboratory of Molecular Engineering of Polymers, Department of Chemistry, Fudan University, Shanghai 200433, China
  c.School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China
- Author bio：
  
  czyao@ahnu.edu.cn
- Funds：
- DOI：10.1007/s10118-026-3797-0
  CLC：
- Received：29 May 2026，
  
  Accepted：30 June 2026，
  
  Online First：22 October 2026，
  
  Published：2026-08
- Accepted：
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Duan, J. L.; Shuai, X.; Chen, T.; Shi, S. Y.; Fan, Y.; Jia, K.; Yao, C. Z. A water-soluble NIR-II polyzwitterionic aza boron dipyrromethene probe with prolonged blood circulation for high-contrast vascular imaging. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3797-0

Ju-Li Duan, Xue Shuai, Tian Chen, et al. A Water-soluble NIR-II Polyzwitterionic Aza Boron Dipyrromethene Probe with Prolonged Blood Circulation for High-contrast Vascular Imaging[J/OL]. Chinese Journal of Polymer Science, 2026, 441-10.
Duan, J. L.; Shuai, X.; Chen, T.; Shi, S. Y.; Fan, Y.; Jia, K.; Yao, C. Z. A water-soluble NIR-II polyzwitterionic aza boron dipyrromethene probe with prolonged blood circulation for high-contrast vascular imaging. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3797-0 DOI：

Ju-Li Duan, Xue Shuai, Tian Chen, et al. A Water-soluble NIR-II Polyzwitterionic Aza Boron Dipyrromethene Probe with Prolonged Blood Circulation for High-contrast Vascular Imaging[J/OL]. Chinese Journal of Polymer Science, 2026, 441-10. DOI： 10.1007/s10118-026-3797-0.

摘要

Abstract

The development of NIR-II fluorescence imaging agents with high aqueous solubility and prolonged circulation

time remains challenging

primarily because of the intrinsic hydrophobicity of the widely used small-molecule fluorophores. Herein

we rationally designed an aza-boron dipyrromethene (BODIPY)-based atom transfer radical polymerization (ATRP) initiator and employed it to polymerize the zwitterionic monomer

2-methacryloyloxyethyl phosphorylcholine (MCP)

yielding a water-soluble polyzwitterionic NIR-II probe

designated as

JNBDP-PMCP

. The resulting

JNBDP-PMCP

exhibited excellent biocompatibility

remarkable chemical/photostability

and a high NIR-II fluorescence quantum yield (

f>1000 nm

=0.032%). Furthermore

its prolonged blood circulation half-life (

1/2

=11.8 h) enables high-fidelity vascular imaging with a superior signal-to-background ratio (SBR). Collectively

this study provides a robust strategy to overcome the solubility and biocompatibility limitations of NIR-II fluorophores

paving the way for advanced bioimaging applications.

关键词

Keywords

references

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