Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair

Hong-Xiang Yin; Yang Wang; Yi-Fei Wu; Jin-Jing Li; Xiao Kong; Wen-Hao Mei; Ze-Tong Wang; Chun-Sheng Xiao; Cheng Zhang; Zhan-Fu Cong; Irshad Hussain; Zhao-Hui Tang; Wei Yan

doi:10.1007/s10118-026-3761-z

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Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair

RESEARCH ARTICLE | Updated：2026-07-20

- Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-9(2026)
- Affiliations：
  
  a.Key Laboratory of Green Preparation and Application for Functional Materials of Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Material Science and Engineering, Hubei University, Wuhan 430062, China
  b.State Key Laboratory of Polymer Science and Technology, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  c.School of Life Science, Hubei University, Wuhan 430062, China
  d.Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
  e.Department of Chemistry and Chemical Engineering, SBA School of Science and Engineering, Lahore University of Management Sciences (LUMS), DHA, Lahore 54792, Pakistan
- Author bio：
  
  zhangcheng1988@hubu.edu.cn (C.Z.)
  ztang@ciac.ac.cn (Z.H.T.)
  willieyan2003@hubu.edu.cn (W.Y.)
- Funds：
- DOI：10.1007/s10118-026-3761-z
  CLC：
- Received：01 April 2026，
  
  Accepted：29 May 2026，
  
  Online First：20 July 2026，
  
  Published：2026-06
- Accepted：
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Yin, H. X.; Wang, Y.; Wu, Y. F.; Li, J. J.; Kong, X.; Mei, W. H.; Wang, Z. T.; Xiao, C. S.; Zhang, C.; Cong, Z. F.; Hussain, I.; Tang, Z. H.; Yan, W. Bioinspired zinc-doped nano hydroxyapatite reinforced poly(lactic acid) composites for bone repair. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3761-z

Hong-Xiang Yin, Yang Wang, Yi-Fei Wu, et al. Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair[J/OL]. Chinese Journal of Polymer Science, 2026, 441-9.
Yin, H. X.; Wang, Y.; Wu, Y. F.; Li, J. J.; Kong, X.; Mei, W. H.; Wang, Z. T.; Xiao, C. S.; Zhang, C.; Cong, Z. F.; Hussain, I.; Tang, Z. H.; Yan, W. Bioinspired zinc-doped nano hydroxyapatite reinforced poly(lactic acid) composites for bone repair. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3761-z DOI：

Hong-Xiang Yin, Yang Wang, Yi-Fei Wu, et al. Bioinspired Zinc-doped Nano Hydroxyapatite Reinforced Poly(lactic acid) Composites for Bone Repair[J/OL]. Chinese Journal of Polymer Science, 2026, 441-9. DOI： 10.1007/s10118-026-3761-z.

摘要

Abstract

Bone defects remain a major clinical challenge due to the slow rate of recovery

complex surgical procedures

and great impact on the lives of patients. Therefore

the development of biocompatible

durable

degradable artificial bone grafts is highly desirable. Inspired by the natural composition of human bone

this study reports the fabrication of poly(lactic acid) (PLA)/zinc-doped hydroxyapatite (Zn-HA) composite materials

via

the melt blending method. The chemical properties

mechanical performance

degradability

and biocompatibility of the composites were evaluated systematically. Among them

the 10 wt% PLA/Zn-HA composite exhibited optimal performance

including high tensile and flexural strengths

superior thermal stability

and the lowest degradation rate. Controlled degradation and sustained release of zinc ions further enhance osteoblast activity with low cytotoxicity. Furthermore

Alkaline Phosphatase (ALP) activity and Alizarin Red S (ARS) staining confirmed that the 10 wt% PLA/Zn-HA composite significantly promoted osteogenic differentiation. By simultaneously achieving mechanical reliability and enhanced biological properties

this study provides promising design criteria for next-generation artifi

cial bone grafts for bone defect repair.

关键词

Keywords

references

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