Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair

Xiao-Yun Han; Wei-Qi Lu; Cheng-Qiang Ye; Ding-Qi Tang; Jia-Rong Wang; Meng Hu; Pei-Hong Ji; Ke-Feng Ren; You-Xiang Wang; Jian Ji

doi:10.1007/s10118-026-3747-x

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Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair

RESEARCH ARTICLE | Updated：2026-09-23

- Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair
- Chinese Journal of Polymer Science Vol. 44, Issue 10, Pages: 3355-3365(2026)
- Affiliations：
  
  a.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
  b.Hangzhou Matrix Medical Technology Co., Ltd., Hangzhou 311100, China
  c.Zhejiang Key Laboratory of Cardiovascular Intervention and Precision Medicine; Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
  d.State Key Laboratory of Transvascular Implantation Devices, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China
- Author bio：
  
  renkf@zju.edu.cn (K.F.R.)
  yx_wang@zju.edu.cn (Y.X.W.)
- Funds：
- DOI：10.1007/s10118-026-3747-x
  CLC：
- Received：14 April 2026，
  
  Accepted：15 May 2026，
  
  Online First：07 August 2026，
  
  Published：05 October 2026
- Accepted：
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Han, X. Y.; Lu, W. Q.; Ye, C. Q.; Tang, D. Q.; Wang, J. R.; Hu, M.; Ji, P. H.; Ren, K. F.; Wang, Y. X.; Ji, J. Polydopamine-modified collagen sponge for improved anti-inflammatory and tissue repair. Chinese J. Polym. Sci. 2026, 44, 3355–3365

Xiao-Yun Han, Wei-Qi Lu, Cheng-Qiang Ye, et al. Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair[J]. Chinese Journal of Polymer Science, 2026, 44(10): 3355-3365.
Han, X. Y.; Lu, W. Q.; Ye, C. Q.; Tang, D. Q.; Wang, J. R.; Hu, M.; Ji, P. H.; Ren, K. F.; Wang, Y. X.; Ji, J. Polydopamine-modified collagen sponge for improved anti-inflammatory and tissue repair. Chinese J. Polym. Sci. 2026, 44, 3355–3365 DOI： 10.1007/s10118-026-3747-x.

Xiao-Yun Han, Wei-Qi Lu, Cheng-Qiang Ye, et al. Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair[J]. Chinese Journal of Polymer Science, 2026, 44(10): 3355-3365. DOI： 10.1007/s10118-026-3747-x.

摘要

The polydopamine-modified collagen sponge was prepared by immersing the collagen sponge in a polydopamine solution. It exhibits excellent antioxidant and anti-inflammatory effects and can promote tissue repair at wound sites.

Abstract

Vascular closure devices (VCDs) play a critical role in preventing bleeding and hematoma formation after percutaneous interventions. Despite effective mechanical hemostasis

the current collagen-based VCDs lack anti-inflammatory and regenerative capabilities. Herein

we report the development of a polydopamine (PDA)-modified collagen sponge (Col@PDA) to enhance the anti-inflammatory and pro-regenerative potential of collagen-based materials. PDA modification not only preserved the sponges’ inherent porosity and swelling

behavior but also endowed them with immunomodulatory functions.

In vitro

the modified sponges exhibited superior anti-inflammatory and antioxidant activities in RAW 264.7 macrophages and L929 fibroblasts. In a rat subcutaneous implantation model

Col@PDA attenuated local inflammation

promoted dermal regeneration

and enhanced collagen deposition and angiogenic factor expression. Collectively

PDA modification enables collagen sponges to actively modulate the healing microenvironment

resulting in faster tissue repair than unmodified collagen sponges.

关键词

Keywords

references

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