Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair

Xiao-Yun Han; Wei-Qi Lu; Cheng-Qiang Ye; Ding-Qi Tang; Jia-Rong Wang; Meng Hu; Pei-Hong Ji; Ke-Feng Ren; You-Xiang Wang; Jian Ji

doi:10.1007/s10118-026-3747-x

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Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair

RESEARCH ARTICLE | Updated：2026-08-07

- Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-11(2026)
- Affiliations：
  
  a.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
  b.Hangzhou Matrix Medical Technology Co., Ltd., Hangzhou 311100, China
  c.Zhejiang Key Laboratory of Cardiovascular Intervention and Precision Medicine; Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
  d.State Key Laboratory of Transvascular Implantation Devices, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China
- Author bio：
  
  renkf@zju.edu.cn (K.F.R.)
  yx_wang@zju.edu.cn (Y.X.W.)
- Funds：
- DOI：10.1007/s10118-026-3747-x
  CLC：
- Received：14 April 2026，
  
  Accepted：15 May 2026，
  
  Online First：07 August 2026，
  
  Published：2026-06
- Accepted：
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Han, X. Y.; Lu, W. Q.; Ye, C. Q.; Tang, D. Q.; Wang, J. R.; Hu, M.; Ji, P. H.; Ren, K. F.; Wang, Y. X.; Ji, J. Polydopamine-modified collagen sponge for improved anti-inflammatory and tissue repair. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3747-x

Xiao-Yun Han, Wei-Qi Lu, Cheng-Qiang Ye, et al. Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair[J/OL]. Chinese Journal of Polymer Science, 2026, 441-11.
Han, X. Y.; Lu, W. Q.; Ye, C. Q.; Tang, D. Q.; Wang, J. R.; Hu, M.; Ji, P. H.; Ren, K. F.; Wang, Y. X.; Ji, J. Polydopamine-modified collagen sponge for improved anti-inflammatory and tissue repair. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3747-x DOI：

Xiao-Yun Han, Wei-Qi Lu, Cheng-Qiang Ye, et al. Polydopamine-modified Collagen Sponge for Improved Anti-inflammatory and Tissue Repair[J/OL]. Chinese Journal of Polymer Science, 2026, 441-11. DOI： 10.1007/s10118-026-3747-x.

摘要

Abstract

Vascular closure devices (VCDs) play a critical role in preventing bleeding and hematoma formation after percutaneous interventions. Despite effective mechanical hemostasis

the current collagen-based VCDs lack anti-inflammatory and regenerative capabilities. Herein

we report the development of a polydopamine (PDA)-modified collagen sponge (Col@PDA) to enhance the anti-inflammatory and pro-regenerative potential of collagen-based materials. PDA modification not only preserved the sponges’ inherent porosity and swelling behavior but also endowed them with immunomodulatory functions.

In vitro

the modified sponges exhibited superior anti-inflammatory and antioxidant activities in RAW 264.7 macrophages and L929 fibroblasts. In a rat subcutaneous implantation model

Col@PDA attenuated local inflammation

promoted dermal regeneration

and enhanced collagen deposition and angiogenic factor expression. Collectively

PDA modification enables collagen sponges to actively modulate the healing microenvironment

resulting in faster tissue repair than unmodified collagen sponges.

关键词

Keywords

references

Napole, A.; Sioutas, G.; Davis, P.; Reddy, C.;Patel, S.; Kandregula, S.; Mannam, S. S.; Jabarkheel, R.; Scott, K. W.; Shekhtman, O.; Burkhardt, J.-K.; Srinivasan, V. M. Comprehensive assessment of the Vecta46 intermediate catheter for neurovascular interventions. Cureus 2025 , 17 , e90577..

Bhogal, S.;Waksman, R. Vascular closure: the ABC’s. Curr. Cardiol. Rep. 2022 , 24 , 355−364..

Noori, V. J.; Eldrup-Jørgensen, J. A systematic review of vascular closure devices for femoral artery puncture sites. J. Vasc Surg. 2018 , 68 , 887−899..

Zhao, P.; Yao, Y.; Yang, Q. ; Wang, N.; Wang, L.; Ma, Q.; Zhang, W. Application of Perclose ProGlide closure device in transbrachial endovascular intervention. Sci. Rep. 2025 , 15 , 2807..

Looby, S.; Keeling, A. N.; McErlean, A.; Given, M. F.; Geoghegan, T.; Lee, M. J. Efficacy and safety of the angioseal vascular closure device post antegrade puncture. CardioVasc. Intervent Radiol. 2008 , 31 , 558−562..

Veasey, R. A.; Large, J. K.; Silberbauer, J.; Paul, G.; Taggu, W.; Ellery, S.; Rathore, V. S.; Lloyd, G. W.; Patel, N. R.; Sulke, A. N. A randomised controlled trial comparing StarClose and AngioSeal vascular closure devices in a district general hospital—the SCOAST study. Int. J. Clin. Pract. 2008 , 62 , 912−918..

Panagrosso, M.; Cavallo, E.; Bracale, U. M.; Peluso, A.; Silvestri, O.; Intrieri, F.; Molinari, V.; Esposito, A.; Trimarchi, S.; Settembrini, A. M.; Lomazzi, C.; La Barbera, G.; Carbonari, L.; Angelini, A.; Morelli, I.; Centonza, E.; Berchiolli, R.; Troisi, N.; Scarati, V.; Artini, V.; De Vivo, S.; Volpe, P.; Massara, M.; Martelli, E. Collagen-based vascular closure device multicenter Italian experience in endovascular aortic aneurysm repair compared with suture-mediated closure vascular device. J. Endovasc. Ther. 2026 , 33 , 692−700..

Scott, M. C.; Spencer, H.J.; Ali, A. T.; Moursi, M. M.; Escobar, G. A.; Lyons, L. C.; Smeds, M. R. Mynx vascular closure device in arterial endovascular procedures. Ann. Vasc. Surg. 2018 , 46 , 112−117..

Haraguchi, T.; Kasai, Y.; Tsujimoto, M.; Kashima, Y.; Sato, K.; Fujita, T. PseuSeal technique: endovascular repair of iatrogenic pseudoaneurysm using ExoSeal. CVIR Endovasc. 2025 , 8 , 21..

Manjari, M. S.; Aaron, K. P.; Muralidharan, C.; Rose, C. Highly biocompatible novel polyphenol cross-linked collagen scaffold for potential tissue engineering applications. React. Funct. Polym. 2020 , 153 , 104630..

Sánchez-Cid, P.; Jiménez-Rosado, M.; Rubio-Valle, J. F.; Romero, A.; Ostos, F. J.; Rafii-El-Idrissi Benhnia, M.; Perez-Puyana, V. Biocompatible and thermoresistant hydrogels based on collagen and chitosan. Polymers 2022 , 14 , 272..

Zhou, T.; Wang, N.; Xue, Y.; Ding, T.; Liu, X.; Mo, X.; Sun, J. Electrospun tilapia collagen nanofibers accelerating wound healing via inducing keratinocytes proliferation and differentiation. Colloids Surf., B 2016 , 143 , 415−422..

Huang, J. Y.; Wong, T. Y.; Tu, T. Y.; Tang, M. J.; Lin, H. H.; Hsueh, Y. Y. Assessment of tilapia skin collagen for biomedical research applications in comparison with mammalian collagen. Molecules 2024 , 29 , 402..

Wang, L.; Li, W.; Qu, Y.; Wang, K.; Lv, K.; He, X.; Qin, S. Preparation of super absorbent and highly active fish collagen sponge and its hemostatic effect in vivo and in vitro. Front. Bioeng. Biotechnol. 2022 , 10 , 862532..

Huang, Z.; Chen, H.; Wang, Y.; Xiao, T.; Guo, T.; Ren, Z.; Wu, C.; Wang, Y. Collagen/curdlan composite sponge for rapid hemostasis and skin wound healing. Int. J. Biol. Macromol. 2024 , 273 , 133032..

Toggweiler, S.; Leipsic, J.; Binder, R. K.; Freeman, M.; Barbanti, M.; Heijmen, R. H.; Wood, D. A.; Webb, J. G. Management of vascular access in transcatheter aortic valve replacement. JACC Cardiovasc Interv. 2013 , 6 , 643−653..

Biancari, F.; D'Andrea, V.; Marco, C. D.; Savino, G.; Tiozzo, V.; Catania, A. Meta-analysis of randomized trials on the efficacy of vascular closure devices after diagnostic angiography and an gioplasty. Am. Heart J. 2010 , 159 , 518−531..

Wei, S.; Shou, Z.; Yang, D.; Sun, L.; Guo, Y.; Wang, Y.; Zan, X.; Li, L.; Zhang, C. Ultra-Long-Term Anti-inflammatory polyphenol capsule to remodel the microenvironment for accelerating osteoarthritis healing by single dosage. Adv. Sci. 2024 , 11 , 2407425..

Kim, S.-H.; Kim, K.; Kim, B. S.; An, Y.-H.; Lee, U.-J.; Lee, S.-H.; Kim, S. L.; Kim, B.-G.; Hwang, N. S. Fabrication of polyphenol-incorporated anti-inflammatory hydrogel via high-affinity enzymatic crosslinking for wet tissue adhesion. Biomaterials 2020 , 242 , 119905..

Boaru, D. L.; Fraile-Martinez, O.; De Leon-Oliva, D.; Garcia-Montero, C.; De Castro-Martinez, P.; Miranda-Gonzalez, A.; Saez, M. A.; Muñon-Zamarron, L.; Castillo-Ruiz, E.; Barrena-Blázquez, S.; Cañonez-Zafra, R.; Alvarez-Mon, M. Á.; Toledo-Lobo, M. V.; Minaya-Bravo, A. M.; Lopez-Gonzalez, L.; Diaz-Pedrero, R.; Saz, J. V.; Albillos, A.; Alvarez-Mon, M.; Guijarro, L. G.; Ortega, M. A. Harnessing the anti-inflammatory properties of polyphenols in the treatment of inflammatory bowel disease. Int. J. Biol. Sci. 2024 , 20 , 5608−5672..

Busto, F.; Scalia, A. C.; Gentile, P.; Toniolo, S.; Cometa, S.; Liotino, S. ; Cochis, A.; Mastrorilli, P.; De Giglio, E. Gellan gum/tannic acid hydrogels for cartilage repair: the versatile role of tannic acid as green crosslinker conferring antibacterial and anti-inflammatory properties. Carbohydr. Polym. Technol. Appl. 2025 , 10 , 100860..

Li, Q.; Wang, L.; Li, Y.; Nan, S.; Tan, Z.; Yang, Q.; Li, C.; Xie, X.; Yan, H.; Hou, G.; Duan, S.; Zhao, Y.-Q. Tannic acid coating modification of polypropylene providing pH-responsive antibacterial and anti-inflammatory properties applicable to ostomy patches. Colloids Surf., B 2025 , 250 , 114567..

Allehyani, E. S.; Almulaiky, Y. Q.; Al-Harbi, S. A.; El-Shishtawy, R. M. In Situ coating of polydopamine-AgNPs on polyester fabrics producing antibacterial and antioxidant properties. Polymers 2022 , 14 , 3794..

Liu, Y.; Li, B.; Yi, C.; Chen, X.; Yu, X. Application of polydopamine as antibacterial and anti-inflammatory materials. Prog. Biomed. Eng. 2025 , 7 , 022005..

[Ye, X.; Pi, Z.; Liu, T.; Wu, B.; Lu, Z.; Tan, Z. 3D-printed PLA/β-TCP scaffold functionalized with PDA and neobavaisoflavone-loaded PEG hydrogel for enhanced bone repair. Colloids Surf., B 2026 , 263 , 115568..

[Liu, L.; Lu, C.; Tao, Z.; Zha, Z.; Wang, H.; Miao, Z. 2D is better: engineering polydopamine into cationic nanosheets to enhance anti-inflammatory capability. Adv. Healthcare Mater . 2024 , 13 , e2400048..

Li, Z.; Wei, W.; Zhang, M.; Guo, X.; Zhang, B.; Wang, D.; Jiang, X.; Liu, F.; Tang, J. Cryptotanshinone-doped photothermal synergistic MXene@PDA nanosheets with antibacterial and anti-inflammatory properties for wound healing. Adv. Healthcare Mater. 2023 , 12 , e2301060..

Wang, C.; Liang, Y.; Huang, Y.; Li, M.; Guo, B. Porous photothermal antibacterial antioxidant dual–crosslinked cryogel based on hyaluronic acid/ polydopamine for non-compressible hemostasis and infectious wound repair. J. Mater. Sci. Technol. 2022 , 121 , 207−219..

Sakib, S.; Andoy, N. M. O.; Yang, J. Y. C.; Galang, A.; Sullan, R. M. A.; Zou, S. Antimicrobial and anti-inflammatory effects of polyethyleneimine-modified polydopamine nanoparticles on a burn-injured skin model. Biomater. Sci. 2025 , 13 , 1770−1783..

Guo, Z.; Zhang, Z.; Zhang, N.; Gao, W.; Li, J.; Pu, Y.; He, B.; Xie, J. A Mg 2+ /polydopamine composite hydrogel for the acceleration of infected wound healing. Bioact. Mater. 2022 , 15 , 203−213..

Liu, C.; Yao, W.; Tian, M.; Wei, J.; Song, Q.; Qiao, W. Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis. Biomaterials 2018 , 179 , 83−95..

Guo, B.; Dong, R.; Liang, Y.; Li, M. Haemostatic materials for wound healing applications. Nat. Rev. Chem. 2021 , 5 , 773−791..

Li, M.; Zhang, Z.; Liang, Y.; He, J.; Guo, B. Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair. ACS Appl. Mater. Interfaces 2020 , 12 , 35856−35872..

Feinberg, H.; Hanks, T. W. Polydopamine: a bioinspired adhesive and surface modification platform. Polym. Int. 2022 , 71 , 578−582..

Ma, Z.-Y.; Li, D.-Y.; Jia, X.; Wang, R.-L.; Zhu, M.-F. Recen t advances in bio-inspired versatile polydopamine platforms for “smart” cancer photothermal therapy. Chinese J. Polym. Sci. 2023 , 41 , 699−712..

Lee, S. E.; Lee, H.; Kim, J. H.; Park, S.; Oh, Y. T.; Choi, H.; Kim, J. M.; Jo, H. J.; Park, J. H.; Jin, H. J.; Lee, K. H.; Han, S.H.; Kim, H.; Oh, J. K.; Kim, B. H. Direct surface modification of the epidermis using mussel-inspired polydopamine with multiple anti-biofouling functions. Adv. Healthcare Mater. 2025 , 14 , 2500597..

Cheng, S.; Wang, D.; Ke, J.; Ma, L.; Zhou, J.; Shao, H.; Zhu, H.; Liu, L.; Zhang, Y.; Peng, F.; Liu, X. Improved in vitro angiogenic behavior of human umbilical vein endothelial cells with oxidized polydopamine coating. Colloids Surf., B. 2020 , 194 , 111176..

Yi, B.; Yu, L.; Tang, H.; Wang, W.; Liu, W.; Zhang, Y. Lysine-doped polydopamine coating enhances antithrombogenicity and endothelialization of an electrospun aligned fibrous vascular graft. Appl. Mater. Today 2021 , 25 , 101198..

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