Silk Sericin-inspired Poly-<italic style="font-style: italic">β</italic>-homoserine for Protein Protection

Jun-Yu Zhang; Jia-Yi Cai; Dong-Hui Zhang; Long-Qiang Liu; Zhong-Hua Zhi; Bing Li; Qi Chen; Run-Hui Liu

doi:10.1007/s10118-026-3691-9

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Silk Sericin-inspired Poly-β-homoserine for Protein Protection

RESEARCH ARTICLE | Updated：2026-08-31

- Silk Sericin-inspired Poly-β-homoserine for Protein Protection
- Chinese Journal of Polymer Science Vol. 44, Issue 9, Pages: 3066-3074(2026)
- Affiliations：
  
  a.State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
  b.Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
  c.State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, China
- Author bio：
  
  rliu@ecust.edu.cn
- Funds：
- DOI：10.1007/s10118-026-3691-9
  CLC：
- Received：15 March 2026，
  
  Accepted：30 March 2026，
  
  Online First：10 July 2026，
  
  Published：05 September 2026
- Accepted：
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Zhang, J. Y.; Cai, J. Y.; Zhang, D. H.; Liu, L. Q.; Zhi, Z. H.; Li, B.; Chen, Q.; Liu, R. H. Silk sericin-inspired poly-β-homoserine for protein protection. Chinese J. Polym. Sci. 2026, 44, 3066–3074

Jun-Yu Zhang, Jia-Yi Cai, Dong-Hui Zhang, et al. Silk Sericin-inspired Poly-β-homoserine for Protein Protection[J]. Chinese Journal of Polymer Science, 2026, 44(9): 3066-3074. DOI: 10.1007/s10118-026-3691-9.
Zhang, J. Y.; Cai, J. Y.; Zhang, D. H.; Liu, L. Q.; Zhi, Z. H.; Li, B.; Chen, Q.; Liu, R. H. Silk sericin-inspired poly-β-homoserine for protein protection. Chinese J. Polym. Sci. 2026, 44, 3066–3074 DOI： 10.1007/s10118-026-3691-9.

Jun-Yu Zhang, Jia-Yi Cai, Dong-Hui Zhang, et al. Silk Sericin-inspired Poly-β-homoserine for Protein Protection[J]. Chinese Journal of Polymer Science, 2026, 44(9): 3066-3074. DOI: 10.1007/s10118-026-3691-9. DOI：

摘要

Sericin exhibits a protein protective function and is characterized by a high serine content

which inspired us to explore the protein-stabilizing effects of poly-

-homoserine (

-HS).

-HS effectively stabilizes proteins with varying physicochemical properties under environmental stresses

such as elevated temperature and lyophilization

highlighting its significant potential for protein stabilization.

Abstract

Protein stability is a critical factor that limits its application in biopharmaceuticals

clinical diagnostics

and industrial production. The inherent instability of proteins renders them susceptible to loss of activity and function under external environmental stresses

thus necessitating the development of novel stabilizers to improve protein stability. Inspired by sericin

we developed heterochiral poly-

-homoserine (

-HS) that combines resistance to enzymatic degradation

straightforward synthesis

and precise composition control

while exhibiting favorable in vitro safety profile. The

-HS exhibits remarkable stabilizing effects on horseradish peroxidase (HRP) and

-galactosidase (

-Gal) when subjected to elevated temperature and lyophilization

respectively. Our research indicates that

-HS stabilizes proteins by assisting in the maintenance of their conformation and preventing aggregation. Additionally

-HS demonstrates stabilizing effects on proteins with diverse physicochemical properties. Therefore

this study suggests that the

-HS is a promising candidate for enhancing protein stability.

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Keywords

references

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Silk Sericin-inspired Poly-β-homoserine for Protein Protection

DOI：10.1007/s10118-026-3691-9

摘要

Abstract

关键词

Keywords

references