

FOLLOWUS
a.College of Chemistry and Chemical Engineering, Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China
b.Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen 361005, China
c.Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
d.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
kaihao@xmu.edu.cn (K.H.)
thy@xmu.edu.cn (H.Y.T.)
Received:28 February 2026,
Accepted:18 March 2026,
Online First:10 June 2026,
Published:15 August 2026
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Li, H. X.; Wu, R. Y.; Mao, X. T.; Zhou, X. R.; Hao, K.; Tian, H. Y. Polymeric nanomedicines for comprehensive regulation of tumor microenvironment. Chinese J. Polym. Sci. 2026, 44, 2427–2452
Hui-Xin Li, Rui-Ying Wu, Xin-Tong Mao, et al. Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment[J]. Chinese Journal of Polymer Science, 2026, 44(8): 2427-2452.
Li, H. X.; Wu, R. Y.; Mao, X. T.; Zhou, X. R.; Hao, K.; Tian, H. Y. Polymeric nanomedicines for comprehensive regulation of tumor microenvironment. Chinese J. Polym. Sci. 2026, 44, 2427–2452 DOI: 10.1007/s10118-026-3678-6.
Hui-Xin Li, Rui-Ying Wu, Xin-Tong Mao, et al. Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment[J]. Chinese Journal of Polymer Science, 2026, 44(8): 2427-2452. DOI: 10.1007/s10118-026-3678-6.
Polymeric nanomedicines provide versatile platforms for comprehensive tumor microenvironment (TME) regulation. By coordinating immune cell modulation and stromal remodeling
these systems dismantle biological barriers and transform “cold” tumors into a “hot” state to maximize synergistic anti-tumor immune activation.
Cancer immunotherapy
which harnesses the host immune system to combat cancer
has advanced into preclinical and clinical trials. However
the tumor microenvironment (TME) usually promotes tumor angiogenesis and induces immune tolerance. Recently
polymeric nanomedicines with comprehensive regulation of the TME have attracted research interest. Compared with others
polymeric nanomedicines have outstanding characteristics
including facile preparation
improved tumor penetration
longer blood circulation
and better bioavailability. In particular
polymeric nanomedicines hold great potential for integrating combined treatments and imaging methods to concurrently modulate and trace the functional processes of multiple immune cells. This review summarizes the advances in polymeric nanomedicine-based strategies for TME regulation
including the regulation of TME stromal cells
the immune microenvironment matrix
and vasculature. Furthermore
the development of comprehensive polymeric nanomedicine-based theragnostic platforms integrated with imaging segments is briefly introduced.
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