Betaine-stabilized Poly(lipoic acid) Adhesive Patch for Oral Ulcer Treatment

Xu-Xuan Yang; Zhen Luo; Jia-Xing Shao; Xue-Quan Feng; Zi-Yang Xu; Chun-Yan Cui; Wen-Guang Liu

doi:10.1007/s10118-026-3592-y

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Betaine-stabilized Poly(lipoic acid) Adhesive Patch for Oral Ulcer Treatment

RESEARCH ARTICLE | Updated：2026-03-13

- Betaine-stabilized Poly(lipoic acid) Adhesive Patch for Oral Ulcer Treatment
- Chinese Journal of Polymer Science Vol. 44, Pages: 1-13(2026)
- Affiliations：
  
  a.School of Material Science and Engineering, Tianjin University, Tianjin 300350, China
  b.The Neurosurgical Department of Tianjin First Central Hospital, Tianjin 300350, China
  c.State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200438, China
- Author bio：
  
  cycui@tju.edu.cn (C.Y.C.)
  wgliu@tju.edu.cn (W.G.L.)
- Funds：
- DOI：10.1007/s10118-026-3592-y
  CLC：
- Received：07 January 2026，
  
  Revised：2026-01-25，
  
  Accepted：27 January 2026，
  
  Online First：13 March 2026，
  
  Published：2026-02
- Accepted：
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Yang, X. X.; Luo, Z.; Shao, J. X.; Feng, X. Q.; Xu, Z. Y.; Cui, C. Y.; Liu, W. G. Betaine-stabilized poly(lipoic acid) adhesive patch for oral ulcer treatment. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3592-y

Xu-Xuan Yang, Zhen Luo, Jia-Xing Shao, et al. Betaine-stabilized Poly(lipoic acid) Adhesive Patch for Oral Ulcer Treatment[J/OL]. Chinese Journal of Polymer Science, 2026, 441-13.
Yang, X. X.; Luo, Z.; Shao, J. X.; Feng, X. Q.; Xu, Z. Y.; Cui, C. Y.; Liu, W. G. Betaine-stabilized poly(lipoic acid) adhesive patch for oral ulcer treatment. Chinese J. Polym. Sci. https://doi.org/10.1007/s10118-026-3592-y DOI：

Xu-Xuan Yang, Zhen Luo, Jia-Xing Shao, et al. Betaine-stabilized Poly(lipoic acid) Adhesive Patch for Oral Ulcer Treatment[J/OL]. Chinese Journal of Polymer Science, 2026, 441-13. DOI： 10.1007/s10118-026-3592-y.

摘要

Abstract

Oral ulce

a prevalent oral mucosal condition

involve epithelial discontinuity

tissue fluid loss

reactive oxygen species accumulation

and bacterial infection. Dynamic saliva flow and physical friction from food residues further aggravate the damage and delay healing. To address this problem

we developed a stable PolyLA-based adhesive patch by combining

-lipoic acid (LA) and betaine (BET) using a simple one-step solvent evaporation method

referred to as PolyLA/BET. The carboxylate and tertiary ammonium groups on BET formed multiple hydrogen bonds with PolyLA

effectively inhibiting the depolymerization of LA. PolyLA/BET firmly adheres to oral tissues

via

hydrogen bonding mediated by surface carboxyl groups. Moreover

zwitterionic structure of BET enabled the patch to absorb and retain water. Upon hydration

the patch maintains structural stability while acquiring flexibility and adhesiveness

which are essential characteristics for durable sealing and the formation of a stable moist wound healing microenvironment. The patch also sustained the release of LA

providing antioxidant and antibacterial activities. In a rat oral ulcer model

PolyLA/BET outperformed the commercial patch in promoting wound healing.

关键词

Keywords

references

Wang, Y.; Pan, Z. Y.; Cui, J.; Zhang, X.; Li, D. W.; Sun, H. C.; Yang, B.; Li, Y. F. Adhesive hydr ogel releases protocatechualdehyde-Fe 3+ complex to promote three healing stages for accelerated therapy of oral ulcers. Acta Biomater. 2024 , 178 , 68−82..

Peres, M. A.; Daly, B.; Guarnizo-Herreno, C. C.; Benzian, H.; Watt, R. G. Oral diseases: a global public health challenge—authors' reply. Lancet 2020 , 395 , 186−187..

Barber, C.; Powell, R.; Ellis, A.; Hewett, J. Comparing pain control and ability to eat and drink with standard therapy vs gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis. Supportive Care in Cancer 2007 , 15 , 427−440..

Zeng, Y. Y.; Gao, Y. J.; He, L. M.; Ge, W. H.; Liu, J. H.; Yu, Y.; Xie, X. Y. Multifunctional polysaccharide composited microneedle for oral ulcers healing. Mater. Today Bio 2023 , 22 , 100782..

Xue, C. C.; Tian, J.; Cui, Z. P.; Liu, Y.; Sun, D. W.; Xiong, M. T.; Yi, N. X.; Wang, K. Q.; Li, X. F.; Xu, H.; Wang, Y. J.; Zhang, W. A.; Liang, Q. Q. Reactive oxygen species (ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession. Bioact. Mater. 2024 , 33 , 545−561..

Zheng, F.; Kelly, M. R.; Ramms, D. J.; Heintschel, M. L.; Tao, K.; Tutuncuoglu, B.; Lee, J. J.; Ono, K.; Foussard, H.; Chen, M.; Herrington, K. A.; Silva, E.; Liu, S. N.; Chen, J.; Churas, C.; Wilson, N.; Kratz, A.; Pillich, R. T.; Patel, D. N.; Park, J.; Kuenzi, B.; Yu, M. K.; Licon, K.; Pratt, D.; Kreisberg, J. F.; Kim, M.; Swaney, D. L.; Nan, X. L.; Fraley, S.; Gutkind, J. S.; Krogan, N. J.; Ideker, T. Interpretation of cancer mutations using a multiscale map of protein systems. Science 2021 , 374 , 51..

Cavallo, I.; Sivori, F.; Mastrofrancesco, A.; Abril, E.; Pontone, M.; Di Domenico, E. G.; Pimpinelli, F. Bacterial biofilm in chronic wounds and possible therapeutic approaches. Biology-Basel 2024 , 13 , 13020109..

Samaranayake, L.; Matsubara, V. H. Normal oral flora and the oral ecosystem. Dent. Clin. N. Am. 2017 , 61 , 199−215..

Al-Omiri, M. K.; Karasneh, J.; Alhijawi, M. M.; Zwiri, A. M.; Scully, C.; Lynch, E. Recurrent aphthous stomatitis (ras): a preliminary within-subject study of quality of life, oral health impacts and personality profiles. J. Oral Pathol. Med. 2015 , 44 , 278−283..

Naglik, J. R.; Konig, A.; Hube, B.; Gaffen, S. L. Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr. Opin. Microbiol. 2017 , 40 , 104−112..

Liu, J. H.; Zhang, Z. P.; Lin, X. F.; Hu, J.; Pan, X. Y.; Jin, A. Q.; Lei, L. J.; Dai, M. H. Magnesium metal-organic framework microneedles loaded with curcumin for accelerating oral ulcer healing. J. Nanobiotechnol. 2024 , 22 , 594..

Superti, F.; Russo, R. Alpha-lipoic acid: Biological mechanisms and health benefits. Antioxidants 2024 , 13 , 13101228..

Martinez-García, K. D.; Zertuche-Arias, T.; Bernáldez-Sarabia, J.; Iñiguez, E.; Kretzchmar, T.; Camacho-Villegas, T. A.; Lugo-Fabres, P. H.; Navarro, A. F. L.; Bravo-Madrigal, J.; Castro-Ceseña, A. B. Radical scavenging, hemocompatibility, and antibacterial activity against mdr in alginate-based aerogels containing lipoic acid-capped silver nanoparticles. ACS Omega 2024 , 9 , 2350−2361..

Skibska, B.; Kochan, E.; Stanczak, A.; Lipert, A.; Skibska, A. Antioxidant and anti-inflammatory effects of α-lipoic acid on lipopolysaccharide-induced oxidative stress in rat kidney. Arch. Immunol. Ther. Ex. 2023 , 71 , 16..

Zoheir, K. M. A.; Ali, N. I.; Ashour, A. E.; Kishta, M. S.; Othman, S. I.; Rudayni, H. A.; Rashad, A. A.; Allam, A. A. Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model. J. Diabetes Metab. Dis. 2025 , 24 , 56..

Cui, C. Y.; Sun, Y. G.; Nie, X. F.; Yang, X. X.; Wang, F. S.; Liu, W. G. A coenzyme-based deep eutectic supramolecular polymer bioadhesive. Adv. Funct. Mater. 2023 , 33 , 202307543..

Cui, C. Y.; Mei, L.; Wang, D. Y.; Jia, P. F.; Zhou, Q. H.; Liu, W. G. A self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer. Nat. Commun. 2023 , 14 , 7707..

Song, H. T.; Qi, Y.; Luo, Z.; Shao, J. X.; Cui, C. Y.; Liu, W. G. A salt-bridge hydrogen bond stabilized poly(lipoic acid)-based bioactive adhesive. Sci. China Technol. Sci. 2025 , 68 , 1720201..

Yu, Q.; Fang, Z. Y.; Luan, S. F.; Wang, L.; Shi, H. C. Biological applications of li poic acid-based polymers: an old material with new promise. J. Mater. Chem. B 2024 , 12 , 4574−4583..

Zhao, X. R.; Wang, F. S.; Sun, Y. G.; Yang, R.; Luo, Z.; Liu, W. G.; Cui, C. Y. An in situ self-solidifying poly(lipoic-acid) liquid adhesive forms pathogen-resistant barrier for ulcerative colitis therapy. ACS Nano 2025 , 19 , 40222−40244..

Song, H. T.; Fu, F.; Chen, Y. Y.; Yang, R.; Luo, Z.; Shao, J. X.; Qi, Y.; Zhang, Q.; Wang, J. J.; Sun, H. T.; Cui, C. Y.; Liu, W. G. A poly(lipoic acid)-based elastomer adhesive with synergistic activity of microenvironment regulation and peripheral neuropathy repair facilitates infectious diabetic wound healing. Biomaterials 2026 , 324 , 123489..

Hu, C. N.; He, J.; He, Y. T.; Peng, Y. J. Anti-freezing conductive gelatin hydrogel reinforced with polypyrrole-decorated cellulose nanofibers for strain sensors and triboelectric nanogenerators. Chinese J. Polym. Sci. 2025 , 43 , 2083−2093..

[Yang, X. X.; Zhang, Q.; Nie, X. F.; Xu, Z. Y.; Liu, W. G. 3D-printed high-stiffness and antiswelling Diels-Alder crosslinked polycarbonate-based polyurethane for meniscal substitution. Sci. China Technol. Sci . 2025, 68 , 1620202..

Wang, L. P.; Guo, L. F.; Zhang, K. Q.; Xia, Y. G.; Hao, J. C.; Wang, X. Development of tough thermoplastic elastomers by leveraging rigid-flexible supramolecular segment interplays. Angew. Chem. Int. Ed. 2023 , 62 , 202301762..

Tan, X.; Hu, X.; Pan, X.; Xie, W.; Li, D.; Yuan, Y.; Wang, J. An integrated janus patch with asymmetric tissue adhesion for enhanced postoperative adhesion prevention. Polymer Science & Technology 2025 , 1 , 120−131..

Cui, C. Y.; Liu, B.; Wu, T. L.; Liu, Y.; Fan, C. C.; Xu, Z. Y.; Yao, Y.; Liu, W. G. A hyperbranched polymer elastomer-based pressure sensitive adhesive. J. Mater. Chem. A 2022 , 10 , 1257−1269..

Qi, Y.; Xu, C. Y.; Zhang, Z. D.; Zhang, Q.; Xu, Z. Y.; Zhao, X. R.; Zhao, Y. H.; Cui, C. Y.; Liu, W. G. Wet environment-induced adhesion and softening of coenzyme-based polymer elastic patch for treating periodontitis. Bioact. Mater. 2024 , 35 , 259−273..

Zhang, Q.; Deng, Y. X.; Luo, H. X.; Shi, C. Y.; Geise, G. M.; Feringa, B. L.; Tian, H.; Qu, D. H. Assembling a natural small molecule into a supramolecular network with high structural order and dynamic functions. J. Am. Chem. Soc. 2019 , 141 , 12804−12814..

Ye, Z. X.; Sun, S. T.; Wu, P. Y. Distinct cation-anion interactions in the UCST and LCST behavior of polyelectrolyte complex aqueous solutions. ACS Macro Lett. 2020 , 9 , 974−979..

Deng, Y. X.; Zhang, Q.; Feringa, B. L.; Tian, H.; Qu, D. H. Toughening a self-healable supramolecular polymer by ionic cluster-enhanced iron-carboxylate complexes. Angew. Chem. Int. Ed. 2020 , 59 , 5278−5283..

Tan, H.; Zhang, L. Z.; Ma, X. P.; Sun, L. J.; Yu, D. L.; You, Z. W. Adaptable covalently cross-linked fibers. Nat. Commun. 2023 , 14 , 2218..

Luo, J. C.; Zhao, X.; Ju, H.; Chen, X. J.; Zhao, S.; Demchuk, Z.; Li, B. R.; Bocharova, V.; Carrillo, J. M. Y.; Keum, J. K.; Xu, S.; Sokolov, A. P.; Chen, J. Y.; Cao, P. F. Highly recyclable and tough elastic vitrimers from a defined polydimethylsiloxane network. Angew. Chem. Int. Ed. 2023 , 62 , e202310989..

Liu, H. C.; Zhou, X. X.; Zhou, S. S.; Zou, Y.; Wang, Y. L.; Li, X. Q. Preparation and properties study of itaconic acid-based degradable epoxy resin based on dynamic covalent bonds. Chinese J. Polym. Sci. 2025 , 43 , 2009−2021..

Sun, S. T.; Wu, P. Y. Spectral insights into microdynamics of thermoresponsive polymers from the perspective of two-dimensional correlation spectroscopy. Chinese J. Polym. Sci. 2017 , 35 , 700−712..

Morita, S.; Shinzawa, H.; Noda, I.; Ozaki, Y. Perturbation-correlation moving-window two-dimensional correlation spectroscopy. Appl. Spectrosc. 2006 , 60 , 398−406..

Chen, A. Q.; An, Y.; Huang, W.; Xuan, T. X.; Zhang, Q. W.; Ye, M. Q.; Luo, S.; Xuan, X.; He, H. C.; Zheng, J.; Wu, J. Highly water-preserving zwitterionic betaine-incorporated collagen sponges with anti-oxidation and anti-inflammation for wound regeneration. Front. Cell Dev. Biol. 2020 , 8 , 202000491..

Bilici, C.; Ide, S.; Okay, O. Yielding behavior of tough semicrystalline hydrogels. Macromolecules 2017 , 50 , 3647−3654..

Wang, Y. J.; Sun, S. T.; Wu, P. Y. Adaptive ionogel paint from room-temperature autonomous polymerization of α-thioctic acid for stretchable and healable electronics. Adv. Funct. Mater. 2021 , 31 , 202101494..

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