Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin

Tatyana U. Kirila; Serafim V. Rodchenko; Nina D. Kozina; Andrey V. Tenkovtsev; Alexander P. Filippov

doi:10.1007/s10118-025-3490-8

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Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin

RESEARCH ARTICLE | Updated：2026-01-30

- Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin
- Chinese Journal of Polymer Science Vol. 44, Issue 2, Pages: 423-436(2026)
- Affiliations：
  
  Branch of Petersburg Nuclear Physics Institute named by B.P. Konstantinov of National Research Centre «Kurchatov Institute»-Institute of Macromolecular Compounds, Saint Petersburg 199004, Russia
- Author bio：
  
  tatyana_pyx@mail.ru
- Funds：
- DOI：10.1007/s10118-025-3490-8
  CLC：
- Received：06 October 2025，
  
  Accepted：27 October 2025，
  
  Published Online：16 January 2026，
  
  Published：05 February 2026
- Accepted：
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Kirila, T. U.; Rodchenko, S. V.; Kozina, N. D.; Tenkovtsev, A. V.; Filippov, A. P. Star-shaped block copolymers of poly-2-alkyl-5,6-dihydrooxazines: synthesis, conformational characteristics, thermoresponsiveness and complexation with curcumin. Chinese J. Polym. Sci. 2026, 44, 423–436

Tatyana U. Kirila, Serafim V. Rodchenko, Nina D. Kozina, et al. Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin[J]. Chinese Journal of Polymer Science, 2026, 44(2): 423-436.
Kirila, T. U.; Rodchenko, S. V.; Kozina, N. D.; Tenkovtsev, A. V.; Filippov, A. P. Star-shaped block copolymers of poly-2-alkyl-5,6-dihydrooxazines: synthesis, conformational characteristics, thermoresponsiveness and complexation with curcumin. Chinese J. Polym. Sci. 2026, 44, 423–436 DOI： 10.1007/s10118-025-3490-8.

Tatyana U. Kirila, Serafim V. Rodchenko, Nina D. Kozina, et al. Star-shaped Block Copolymers of Poly-2-alkyl-5,6-dihydrooxazines: Synthesis, Conformational Characteristics, Thermoresponsiveness and Complexation with Curcumin[J]. Chinese Journal of Polymer Science, 2026, 44(2): 423-436. DOI： 10.1007/s10118-025-3490-8.

摘要

Star-shaped polymers with hexaaza[2

]

orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5

6-dihydrooxazine with poly-2-isopropyl-5

6-dihydrooxazine were synthesized. The molecular conformation has been determined. Complexes of polymer stars with curcumin were obtained. The influence of the structure and molar mass of star copolymer on efficient binding and thermoresponsiveness of complexes was analyzed.

Abstract

Star-shaped six-arm polymers with hexaaza[2

]

orthoparacyclophane core and arms of block copolymers of poly-2-ethyl-5

6-dihydrooxazine with poly-2-isopropyl-5

6-dihydrooxazine were synthesized successfully using cationic ring-opening polymerization. The ratio of blocks

the order of their attachment to the core

and arm length were varied. Conformation of synthesized stars was determined by methods of molecular hydrodynamics and optics. It has been shown that star-shaped molecules were characterized by high intramolecular density

and the arm folding increased with their lengthening. The influence of the structure of block copolymers and their molar mass on the critical micelle concentration has been established. Complexes of synthesized star-shaped block copolymers with curcumin were obtained and the efficient binding of curcumin to polymer molecules was demonstrated. The behavior of the aqueous solutions of the prepared polymer stars and their complexes with curcumin was investigated by light scattering and turbidimetry methods. The influence of the structure and mola

r mass of star polymers on their thermoresponsiveness and the phase separation temperatures in aqueous solutions was analyzed. A slight increase in the phase separation temperature was found on passage from polymer solutions to solutions of polymer complexes with hydrophobic curcumin.

关键词

Keywords

references

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