Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine

Ye-Qian Ruan; Xuan Kuang; Rui Kuang

doi:10.1007/s10118-025-3425-4

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Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine

RESEARCH ARTICLE | Updated：2025-10-30

- Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine
- Chinese Journal of Polymer Science Vol. 43, Issue 11, Pages: 2110-2117(2025)
- Affiliations：
  
  a.Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
  b.College of Traffic Civil Engineering, Shandong Jiaotong University, Jinan 250023, China
- Author bio：
  
  chm_kuangx@ujn.edu.cn (X.K.)
  kuangr1985@foxmail.com (R.K.)
- Funds：
- DOI：10.1007/s10118-025-3425-4
  CLC：
- Received：09 June 2025，
  
  Accepted：02 August 2025，
  
  Online First：16 October 2025，
  
  Published：05 November 2025
- Accepted：
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Ruan, Y. Q.; Kuang, X.; Kuang, R. Metal-organic framework/polyimide-electrochemiluminescence sensor for enantioselective detection of histidine. Chinese J. Polym. Sci. 2025, 43, 2110–2117

Ye-Qian Ruan, Xuan Kuang, Rui Kuang. Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine[J]. Chinese Journal of Polymer Science, 2025, 43(11): 2110-2117.
Ruan, Y. Q.; Kuang, X.; Kuang, R. Metal-organic framework/polyimide-electrochemiluminescence sensor for enantioselective detection of histidine. Chinese J. Polym. Sci. 2025, 43, 2110–2117 DOI： 10.1007/s10118-025-3425-4.

Ye-Qian Ruan, Xuan Kuang, Rui Kuang. Metal-Organic Framework/Polyimide-Electrochemiluminescence Sensor for Enantioselective Detection of Histidine[J]. Chinese Journal of Polymer Science, 2025, 43(11): 2110-2117. DOI： 10.1007/s10118-025-3425-4.

摘要

This study introduces a novel chiral MOF/PI-ECL sensor

utilizing a linear polyimide chain and ferrocene as key components for highly sensitive and enantioselective detection of histidine. The sensor demonstrates an impressive LOD of 8 μM and excellent recovery rates in real samples.

Abstract

In this study

a novel linear polyimide chain (PTCDA-DCH) was used as an electrochemiluminescence (ECL) emitter

employing a chiral metal-organic framework (MOF) (Zn-Dcam-dabco) as the chiral selector and ferrocene (Fc) as a quencher to construct a chiral sensor for detecting histidine (His) enantiomers. Competitive interactions between Fc and His induce partial Fc desorption from the sensor surface

leading to ECL signal recovery. Differential Fc release due to the distinct binding affinities of Zn-Dcam-dabco for His enantiomers enabled precise chiral discrimination. Notably

the sensor achieved the quantitative detection of His enantiomers with an limits of detection (LOD) of 8 μmol/L. Furthermore

the sensor demonstrated excellent recovery rates of 98.0%–104% for l-histidine (L-His) and 92.0%–95.9% for D-His in spiked milk samples

validating its reliability for real-sample analysis. This study provides a promising platform for ECL-based chiral recognition

bioanalysis

and the rapid assessment of amino acids in food products.

关键词

Keywords

references

Chang, W. X.; Liu, M. Y.; Ren, Q.;Shi, Z. S.; Wang, W.; Nie, J.-Y.; Cai, Z. W. Enantioselective behavior and bioactivity of chiral tebuconazole in apples. Food Control 2023 , 153 , 109941..

[Sardella, R.; Lisanti, A.; Marinozzi, M.; Ianni, F.; Natalini, B.; Blanch, G. P.; Castillo, M. L. R. Combined monodimensional chromatographic approaches to monitor the presence of d-amino acids in cheese. Food Control 2013 , 34 , 478-487..

Zhong, J.-J.; Xia, L.; Xue, L.; Liu, B.; Zhao, L.; Ye, H.; Li, Z. Analytical method for histamine, urocanic acid isomers, and their precursor histidine in fish sauce based on precolumn dansylation and high-performance liquid chromatography. Food Control 2023 , 147 , 109566..

Messer, L. F.; Bourne, D. G.; Robbins, S. J.; Clay, M.; Bell, S. C.; Mclloroy, S. J.; Tyson, G. W. A genome-centric view of the role of the acropora kenti microbiome in coral health and resilience. Nat. Commun. 2024 , 15 , 2902..

Morte, L. B.; Moniente, M.; Ramirez, Y. G.; Virto, R.; Gonzalo, D. G.; Pagan, R. Identification by means of molecular tools of the microbiota responsible for the formation of histamine accumulated in commercial cheeses in spain. Food Control 2022 , 133 , 108595..

[Zhang, J. H.; Liang, R. X.; Huang, B.; Yu, L. Q.; Chen, J.; Wang, B. J.; Xie, S. M.; Yuan, L. M. Preparation of a homochiral me tal-organic cage and its bonded silicas for efficient enantioseparation in high-performance liquid chromatography and gas chromatography. Chin. Chem. Lett . 2025 , 111146..

Kobidze, G.; Sprega, G.; Faro, A. F. L.; Balloni, A.; Peluso, P.; Farkas, T.; Karckhadze, M.; Basile, G.; Busardo, F. P.; Chankvetadze, B. Insights into the separation, enantioseparation and recognition mechanisms of methamphetamine isotopologues on achiral and polysaccharide-based chiral columns in high-performance liquid chromatography. Anal. Chim. Acta 2025 , 1337 , 343542..

Gogolashvili, A.; Tatunashvili, E.; Chankvetadze, L.; Giunashvili, L.; Hefnawy, M.; Ali, I. Chiral separation of pharmaceuticals and agrochemicals using capillary electrophoresis: Migration order, modeling and chiral recognition mechanism. Talanta 2025 , 293 , 128004..

Zhang, Q.; Ren, S.; Xue, S.; Li, A.; Liu, S.; Sun, X. Tetraalkylammonium-l-tartrate ionic liquids as sole chiral selectors in capillary electrophoresis. Sep. Purif. Technol. 2021 , 256 , 117842..

[Lee, K. W.; Hassan, A. H. E.; Jeong, Y.; Yoon, S.; Kim, S. H.; Lee, C. J.; Jeon, H. R.; Chang, S. W.; Kim, J. Y.; Jang, D. S.; Kim, H. J.; Cheong, J.-H.; Lee, Y.-S. Enantiopure methoxetamine stereoisomers: Chiral resolution, conformational analysis, UV-circular dichroism spectroscopy and electronic circular dichroism. New J. Chem. 2021 , 45 , 4354−4364..

Gao, L.; Hu, X.; Qin, S.; Chu, H.; Zhao, X.; Wang, B. L-cysteine modified metal–organic framework as a chiral stationary phase for enantioseparation by capillary electrochromatography. RSC Adv. 2022 , 12 , 6063−6075..

Wang, D.; Wang, P.; Liang, Z.; Li, Z.; Liu, N.; Ma, Q. Novel Cu nanocluster superlattice/mbene-induced ecl enhancement strategy for mirna-221 detection. Chem. Eng. J. 2023 , 478 , 147512..

Zhai, T.; Zhang, Q.; Yang, F.; Zhou, H.; Hao, T.; Guo, Z.; Chen, Z. A green EC/ECL dual-mode biosensing platform for detection of vibrio parahaemolyticus. Sens. Actuators B Chem. 2024 , 415 , 136010..

[Wang, J.; Han, Z.; Shang, T.; Feng, Y.; Liu, R.; Lu, X. Artemisinin: A novel chiral electrochemiluminescence luminophore-assisted enantiospecific recognition and mechanism identification. Chem. Sci. 2024 , 15 , 5581−5588..

Wang, Z.; Ren, Y.; Zhou, B.; Chen, Z.; Wang, Z.; Wang, J.; Wang, J. Rapid determination for tyrosine isomers in food based on N-acetyl-l-cysteine/upconversion nanomaterials target-induced quench by chiral electrochemiluminescence sensor. Food Chem. 2025 , 463 , 141169..

Zhang, W.; Cui, X.; Li, F.; Yan, W.; Wang, Y.; Shang, L.; Ma, R.; Jia, L.; Li, C.; Wang, H. Perylene diimide and g-C 3 N 4 nanosheet as potential-resolved cathode luminophores for ultrasensitive ratiometric electrochemiluminescence immunosensor. Sensor Actuat B-Chem 2022 , 371 , 132492..

Zhao, L. Y.; Zhao, H. Q.; Shang, L.; Shen, G. D.; Ma, R. N.; Wang, H. S. A robust ECL-enhanced system based on UiO-66-COOH promoting perylene diimide derivative electrochemiluminescence for tumor biomarker detection. Sensor Actuat B-Chem 2025 , 423 , 136824..

[Zhang, Y.; Li, Z.; Du, J.; Jie, G.; Zhou, H. Potential-resolved ratio electrochemiluminescence biosensor based on perylene diimide-MOF and DNA nanoflowers–CdS quantum dots for detection of dual targets. Anal. Chem , 2024 , 96 , 13690−13698..

[Cao, W.; Ferrance, J. P.; Demas, J.; Landers, J. P. Quenching of the electrochemiluminescence of tris(2,2‘-bipyridine)ruthenium(II) by ferrocene and its potential application to quantitative DNA detection. J. Am. Chem. Soc. 2006 , 128 , 7572−7578..

Sha, H.; Zhang, Y.; Wang, Y.; Ke, H.; Xiong, X.; Xue, H.; Jia, N. Electroluminescent aptasensor based on RuSiO 2 nanoparticles for detection cytochrome c using ferrocene as quenching probe. Biosens. Bioelectron. 2019 , 132 , 203−209..

[Thoonen, S.; Siripanich, P.; Hua, L.; Tay, H. M.; Ramkissoon, P.; Smith, T. A.; Lessio, M.; Hua,C. Enhancing enantioselectivity in chiral metal organic framework fluorescent sensors. Inorg. Chem. Front. 2024 , 11 , 3877−3888..

[Ye, N.; Ma, J.; An, J.; Li, J.; Cai, Z.; Zong, H. Separation of amino acid enantiomers by a capillary modified with a metal–organic framework. RSC Adv. 2016 , 6 , 41587−41593..

[Zhao, X.; Nguyen, E. T.; Hong, A. N.; Feng, P.; Bu, X. Chiral isocamphoric acid: Founding a large fa mily of homochiral porous materials. Angew. Chem. Int. Ed. 2018 , 57 , 7101−7105..

Dybtsev, D. N.; Yutkin, M. P.; Peresypkina, E. V.; Virovets, A. V.; Serre, C.; Ferey, G.; Fedin, V. P. Isoreticular homochiral porous metal−organic structures with tunable pore sizes. Inorg. Chem. 2007 , 46 , 17..

Hatamluyi, B.; Sadeghzadeh, S.; Sadeghian, R.; Mirimoghaddam, M. M.; Boroushaki, M. T. A signal on-off ratiometric electrochemical sensing platform coupled with a molecularly imprinted polymer and CuCo 2 O 4 /NCNTs signal amplification for selective determination of gemcitabine. Sens. Actuators B Chem. 2022 , 371 , 132552..

Chu, Y.; Han, T.; Deng, A.; Li, L.; Zhu, J. J. Resonance energy transfer in electrochemiluminescent and photoelectrochemical bioanalysis. TrAC Trends Anal. Chem. 2020 , 123 , 115745..

Wang, X.; Jia, C.; Wang, S.; Dong, Y. Coreactant-free strong Ru(bpy) 3 2+ ECL at ionic liquid modified electrode and its application in sensitive detection of glucose based on resonance energy transfer. Talanta 2024 , 270 , 125584..

Yan, Y.; Wang, X. Y.; Hai, X.; Song, W.; Ding, C.; Cao, J.; Bi, S. Chemiluminescence resonance energy transfer: From mechanisms to analytical applications. TrAC Trends Anal. Chem. 2020 , 123 , 115755..

[Yang, X.; Wei, Y.; Wang, Z.; Wang, J.; Qi, H.; Gao, Q.; Zhang, C. ECL highly efficient electrogenerated chemiluminescence quenching on lipid-coated multifunctional magnetic nanoparticles for the determination of proteases. Anal. Chem. 2022 , 94 , 2305−2312..

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